Molecular Genetic Characterisation of Frontotemporal Dementia on Chromosome 3

We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide rep...

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Veröffentlicht in:	Dementia and geriatric cognitive disorders 1999-01, Vol.10 (Suppl 1), p.93-101
Hauptverfasser:	Ashworth, Anthony, Lloyd, Sarah, Brown, Jeremy, Gydesen, Susanne, Sorensen, S. Asger, Brun, Arne, Englund, Elisabet, Humphreys, Christine, Housman, David, Badura, Mary, Stanton Jr, Vincent, Taylor, Kay, Cameron, Jessica, Munroe, David, Johansson, Jenni, Rossor, Martin, Fisher, Elizabeth M.C., Collinge, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Child Chromosomes, Human, Pair 3 - physiology Cosmids - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia Dementia - genetics Dementia - metabolism Denmark Disease Progression DNA Fingerprinting Frontal Lobe - metabolism Genetic Linkage - genetics Humans Immunohistochemistry Medical sciences Neurology Pedigree Temporal Lobe - metabolism Trinucleotide Repeats
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Zusammenfassung:	We have previously localized a locus causing familial nonspecific dementia to the centromeric region of chromosome 3 in a pedigree from the Jutland area of Denmark. This pedigree shows anticipation. Here we present further analysis of these anticipation data which are suggestive of trinucleotide repeat expansion involvement. We also outline our strategies to clone the mutant gene via its putative associated trinucleotide repeat sequence.
ISSN:	1420-8008 1421-9824
DOI:	10.1159/000051222