Continuous Renal Replacement Therapy with oXiris® Membrane in Severe Ebstein-Barr Virus-Mediated Hemophagocytic Lymphohistiocytosis: A Case Report

Abstract Hemophagocytic lymphohistiocytosis (HLH), a life-threatening disease with uncontrolled immune activation and inflammatory reaction, often leads to a deadly cytokine storm. In severe Ebstein-Barr virus-triggered HLH receiving standard immunosuppression, continuous renal replacement therapy (...

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Veröffentlicht in:	Blood purification 2021-07, Vol.50 (4-5), p.578-581
Hauptverfasser:	Samman, Karla N., Baalbaki, Hussein, Bouchard, Josée, Albert, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case Report Continuous Renal Replacement Therapy - instrumentation Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - therapy Herpesvirus 4, Human - isolation & purification Humans Lymphohistiocytosis, Hemophagocytic - therapy Lymphohistiocytosis, Hemophagocytic - virology Male Young Adult
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Zusammenfassung:	Abstract Hemophagocytic lymphohistiocytosis (HLH), a life-threatening disease with uncontrolled immune activation and inflammatory reaction, often leads to a deadly cytokine storm. In severe Ebstein-Barr virus-triggered HLH receiving standard immunosuppression, continuous renal replacement therapy (CRRT) with oXiris® blood purification membrane resulted in a timely reduction of inflammatory markers and discontinuation of vasopressors. To our knowledge, this is the first report of successful use of the oXiris® membrane in HLH.
ISSN:	0253-5068 1421-9735
DOI:	10.1159/000511724