Assessment of Patients with Intracerebral Hemorrhage or Hemorrhagic Transformation in the VENOST Study

Introduction: Cerebral venous and sinus thrombosis (CVST) may lead to cerebral edema and increased intracranial pressure; besides, ischemic or hemorrhagic lesions may develop. Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the ce...

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Veröffentlicht in:European neurology 2020, Vol.83 (6), p.615-621
Hauptverfasser: Duman, Taşkın, Yayla, Vildan, Uludüz, Derya, Özaydın Göksu, Eylem, Yürekli, Vedat Ali, Genç, Hamit, Utku, Uygar, Çınar, Nilgün, Tekeli, Hakan, Sungur, Mehmet Ali, Tokuç, Firdevs Ezgi, Uzuner, Nevzat, Şenol, Mehmet Güney, Yılmaz, Arda, Gökçe, Mustafa, Demirci, Seden, Küsbeci, Özge Yılmaz, Uzuner, Gülnur Tekgöl, Şahin, Şevki, Batur Çağlayan, Hale Zeynep, Açıkgöz, Mustafa, Özdağ, Fatih, Baybaş, Sevim, Ekmekçi, Hakan, Çabalar, Murat, Yaman, Mehmet, Bektaş, Hesna, Kaplan, Yüksel, Göksel, Başak Karakurum, Milanlıoğlu, Aysel, Necioğlu Örken, Dilek, Aluçlu, Mehmet Ufuk, Çolakoğlu, Sena, Tüfekçi, Ahmet, Bakar, Mustafa, Nazlıel, Bijrn, Taşçılar, Nida, Göksan, Baki, Kozak, Hasan Hüseyin, Mısırlı, Handan, Küçükoğlu, Hayriye, Midi, İpek, Mengüllüoğlu, Necdet, Aytaç, Emrah, Yeşilot, Nilüfer, İnce, Birsen, Yalın, Osman Özgür, Güneş, Taşkın, Oruç, Serdar, Mayda Domaç, Füsun, Öztürk, Şerefnur, Karahan, Ali, Erdoğan, Hacı Ali, Afşar, Nazire
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container_issue 6
container_start_page 615
container_title European neurology
container_volume 83
creator Duman, Taşkın
Yayla, Vildan
Uludüz, Derya
Özaydın Göksu, Eylem
Yürekli, Vedat Ali
Genç, Hamit
Utku, Uygar
Çınar, Nilgün
Tekeli, Hakan
Sungur, Mehmet Ali
Tokuç, Firdevs Ezgi
Uzuner, Nevzat
Şenol, Mehmet Güney
Yılmaz, Arda
Gökçe, Mustafa
Demirci, Seden
Küsbeci, Özge Yılmaz
Uzuner, Gülnur Tekgöl
Şahin, Şevki
Batur Çağlayan, Hale Zeynep
Açıkgöz, Mustafa
Özdağ, Fatih
Baybaş, Sevim
Ekmekçi, Hakan
Çabalar, Murat
Yaman, Mehmet
Bektaş, Hesna
Kaplan, Yüksel
Göksel, Başak Karakurum
Milanlıoğlu, Aysel
Necioğlu Örken, Dilek
Aluçlu, Mehmet Ufuk
Çolakoğlu, Sena
Tüfekçi, Ahmet
Bakar, Mustafa
Nazlıel, Bijrn
Taşçılar, Nida
Göksan, Baki
Kozak, Hasan Hüseyin
Mısırlı, Handan
Küçükoğlu, Hayriye
Midi, İpek
Mengüllüoğlu, Necdet
Aytaç, Emrah
Yeşilot, Nilüfer
İnce, Birsen
Yalın, Osman Özgür
Güneş, Taşkın
Oruç, Serdar
Mayda Domaç, Füsun
Öztürk, Şerefnur
Karahan, Ali
Erdoğan, Hacı Ali
Afşar, Nazire
description Introduction: Cerebral venous and sinus thrombosis (CVST) may lead to cerebral edema and increased intracranial pressure; besides, ischemic or hemorrhagic lesions may develop. Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the cerebral hemorrhage (CH) group and the CVST group. Materials and Methods: In the VENOST study, medical records of 1,193 patients with CVST, aged over 18 years, were obtained from 35 national stroke centers. Demographic characteristics, clinical symptoms, signs at the admission, radiological findings, etiologic factors, acute and maintenance treatment, and outcome results were reported. The number of involved sinuses or veins, localizations of thrombus, and lesions on CT and MRI scans were recorded. Results: CH was detected in the brain imaging of 241 (21.1%) patients, as hemorrhagic infarction in 198 patients and intracerebral hemorrhage in 43 patients. Gynecologic causes comprised the largest percentage (41.7%) of etiology and risk factors in the CVST group. In the CH group, headache associated with other neurological symptoms was more frequent. These neurological symptoms were epileptic seizures (46.9%), nausea and/or vomiting (36.5%), altered consciousness (36.5%), and focal neurological deficits (33.6%). mRS was ≥3 in 23.1% of the patients in the CH group. Discussion and Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome.
doi_str_mv 10.1159/000510627
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Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the cerebral hemorrhage (CH) group and the CVST group. Materials and Methods: In the VENOST study, medical records of 1,193 patients with CVST, aged over 18 years, were obtained from 35 national stroke centers. Demographic characteristics, clinical symptoms, signs at the admission, radiological findings, etiologic factors, acute and maintenance treatment, and outcome results were reported. The number of involved sinuses or veins, localizations of thrombus, and lesions on CT and MRI scans were recorded. Results: CH was detected in the brain imaging of 241 (21.1%) patients, as hemorrhagic infarction in 198 patients and intracerebral hemorrhage in 43 patients. Gynecologic causes comprised the largest percentage (41.7%) of etiology and risk factors in the CVST group. In the CH group, headache associated with other neurological symptoms was more frequent. These neurological symptoms were epileptic seizures (46.9%), nausea and/or vomiting (36.5%), altered consciousness (36.5%), and focal neurological deficits (33.6%). mRS was ≥3 in 23.1% of the patients in the CH group. Discussion and Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome.</description><identifier>ISSN: 0014-3022</identifier><identifier>EISSN: 1421-9913</identifier><identifier>DOI: 10.1159/000510627</identifier><identifier>PMID: 33130674</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adolescent ; Adult ; Aged ; Cerebral Hemorrhage - epidemiology ; Cerebral Hemorrhage - etiology ; Clinical Neurology: Research Article ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Sinus Thrombosis, Intracranial - complications ; Sinus Thrombosis, Intracranial - diagnosis ; Young Adult</subject><ispartof>European neurology, 2020, Vol.83 (6), p.615-621</ispartof><rights>2020 S. Karger AG, Basel</rights><rights>2020 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-bfcd6142293b7d03950c95b9095f18fd41178bfe82bc06089315c05478d10f783</citedby><cites>FETCH-LOGICAL-c334t-bfcd6142293b7d03950c95b9095f18fd41178bfe82bc06089315c05478d10f783</cites><orcidid>0000-0002-4961-4332 ; 0000-0001-5876-8643</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33130674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duman, Taşkın</creatorcontrib><creatorcontrib>Yayla, Vildan</creatorcontrib><creatorcontrib>Uludüz, Derya</creatorcontrib><creatorcontrib>Özaydın Göksu, Eylem</creatorcontrib><creatorcontrib>Yürekli, Vedat Ali</creatorcontrib><creatorcontrib>Genç, Hamit</creatorcontrib><creatorcontrib>Utku, Uygar</creatorcontrib><creatorcontrib>Çınar, Nilgün</creatorcontrib><creatorcontrib>Tekeli, Hakan</creatorcontrib><creatorcontrib>Sungur, Mehmet Ali</creatorcontrib><creatorcontrib>Tokuç, Firdevs Ezgi</creatorcontrib><creatorcontrib>Uzuner, Nevzat</creatorcontrib><creatorcontrib>Şenol, Mehmet Güney</creatorcontrib><creatorcontrib>Yılmaz, Arda</creatorcontrib><creatorcontrib>Gökçe, Mustafa</creatorcontrib><creatorcontrib>Demirci, Seden</creatorcontrib><creatorcontrib>Küsbeci, Özge Yılmaz</creatorcontrib><creatorcontrib>Uzuner, Gülnur Tekgöl</creatorcontrib><creatorcontrib>Şahin, Şevki</creatorcontrib><creatorcontrib>Batur Çağlayan, Hale Zeynep</creatorcontrib><creatorcontrib>Açıkgöz, Mustafa</creatorcontrib><creatorcontrib>Özdağ, Fatih</creatorcontrib><creatorcontrib>Baybaş, Sevim</creatorcontrib><creatorcontrib>Ekmekçi, Hakan</creatorcontrib><creatorcontrib>Çabalar, Murat</creatorcontrib><creatorcontrib>Yaman, Mehmet</creatorcontrib><creatorcontrib>Bektaş, Hesna</creatorcontrib><creatorcontrib>Kaplan, Yüksel</creatorcontrib><creatorcontrib>Göksel, Başak Karakurum</creatorcontrib><creatorcontrib>Milanlıoğlu, Aysel</creatorcontrib><creatorcontrib>Necioğlu Örken, Dilek</creatorcontrib><creatorcontrib>Aluçlu, Mehmet Ufuk</creatorcontrib><creatorcontrib>Çolakoğlu, Sena</creatorcontrib><creatorcontrib>Tüfekçi, Ahmet</creatorcontrib><creatorcontrib>Bakar, Mustafa</creatorcontrib><creatorcontrib>Nazlıel, Bijrn</creatorcontrib><creatorcontrib>Taşçılar, Nida</creatorcontrib><creatorcontrib>Göksan, Baki</creatorcontrib><creatorcontrib>Kozak, Hasan Hüseyin</creatorcontrib><creatorcontrib>Mısırlı, Handan</creatorcontrib><creatorcontrib>Küçükoğlu, Hayriye</creatorcontrib><creatorcontrib>Midi, İpek</creatorcontrib><creatorcontrib>Mengüllüoğlu, Necdet</creatorcontrib><creatorcontrib>Aytaç, Emrah</creatorcontrib><creatorcontrib>Yeşilot, Nilüfer</creatorcontrib><creatorcontrib>İnce, Birsen</creatorcontrib><creatorcontrib>Yalın, Osman Özgür</creatorcontrib><creatorcontrib>Güneş, Taşkın</creatorcontrib><creatorcontrib>Oruç, Serdar</creatorcontrib><creatorcontrib>Mayda Domaç, Füsun</creatorcontrib><creatorcontrib>Öztürk, Şerefnur</creatorcontrib><creatorcontrib>Karahan, Ali</creatorcontrib><creatorcontrib>Erdoğan, Hacı Ali</creatorcontrib><creatorcontrib>Afşar, Nazire</creatorcontrib><title>Assessment of Patients with Intracerebral Hemorrhage or Hemorrhagic Transformation in the VENOST Study</title><title>European neurology</title><addtitle>Eur Neurol</addtitle><description>Introduction: Cerebral venous and sinus thrombosis (CVST) may lead to cerebral edema and increased intracranial pressure; besides, ischemic or hemorrhagic lesions may develop. Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the cerebral hemorrhage (CH) group and the CVST group. Materials and Methods: In the VENOST study, medical records of 1,193 patients with CVST, aged over 18 years, were obtained from 35 national stroke centers. Demographic characteristics, clinical symptoms, signs at the admission, radiological findings, etiologic factors, acute and maintenance treatment, and outcome results were reported. The number of involved sinuses or veins, localizations of thrombus, and lesions on CT and MRI scans were recorded. Results: CH was detected in the brain imaging of 241 (21.1%) patients, as hemorrhagic infarction in 198 patients and intracerebral hemorrhage in 43 patients. Gynecologic causes comprised the largest percentage (41.7%) of etiology and risk factors in the CVST group. In the CH group, headache associated with other neurological symptoms was more frequent. These neurological symptoms were epileptic seizures (46.9%), nausea and/or vomiting (36.5%), altered consciousness (36.5%), and focal neurological deficits (33.6%). mRS was ≥3 in 23.1% of the patients in the CH group. Discussion and Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Cerebral Hemorrhage - epidemiology</subject><subject>Cerebral Hemorrhage - etiology</subject><subject>Clinical Neurology: Research Article</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sinus Thrombosis, Intracranial - complications</subject><subject>Sinus Thrombosis, Intracranial - diagnosis</subject><subject>Young 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Ali ; Erdoğan, Hacı Ali ; Afşar, Nazire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-bfcd6142293b7d03950c95b9095f18fd41178bfe82bc06089315c05478d10f783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Cerebral Hemorrhage - epidemiology</topic><topic>Cerebral Hemorrhage - etiology</topic><topic>Clinical Neurology: Research Article</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sinus Thrombosis, Intracranial - complications</topic><topic>Sinus Thrombosis, Intracranial - diagnosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duman, Taşkın</creatorcontrib><creatorcontrib>Yayla, Vildan</creatorcontrib><creatorcontrib>Uludüz, Derya</creatorcontrib><creatorcontrib>Özaydın Göksu, Eylem</creatorcontrib><creatorcontrib>Yürekli, Vedat Ali</creatorcontrib><creatorcontrib>Genç, Hamit</creatorcontrib><creatorcontrib>Utku, Uygar</creatorcontrib><creatorcontrib>Çınar, Nilgün</creatorcontrib><creatorcontrib>Tekeli, Hakan</creatorcontrib><creatorcontrib>Sungur, Mehmet Ali</creatorcontrib><creatorcontrib>Tokuç, Firdevs Ezgi</creatorcontrib><creatorcontrib>Uzuner, Nevzat</creatorcontrib><creatorcontrib>Şenol, Mehmet Güney</creatorcontrib><creatorcontrib>Yılmaz, Arda</creatorcontrib><creatorcontrib>Gökçe, Mustafa</creatorcontrib><creatorcontrib>Demirci, Seden</creatorcontrib><creatorcontrib>Küsbeci, Özge Yılmaz</creatorcontrib><creatorcontrib>Uzuner, Gülnur Tekgöl</creatorcontrib><creatorcontrib>Şahin, Şevki</creatorcontrib><creatorcontrib>Batur Çağlayan, Hale Zeynep</creatorcontrib><creatorcontrib>Açıkgöz, Mustafa</creatorcontrib><creatorcontrib>Özdağ, Fatih</creatorcontrib><creatorcontrib>Baybaş, Sevim</creatorcontrib><creatorcontrib>Ekmekçi, Hakan</creatorcontrib><creatorcontrib>Çabalar, Murat</creatorcontrib><creatorcontrib>Yaman, Mehmet</creatorcontrib><creatorcontrib>Bektaş, Hesna</creatorcontrib><creatorcontrib>Kaplan, Yüksel</creatorcontrib><creatorcontrib>Göksel, Başak Karakurum</creatorcontrib><creatorcontrib>Milanlıoğlu, Aysel</creatorcontrib><creatorcontrib>Necioğlu Örken, Dilek</creatorcontrib><creatorcontrib>Aluçlu, Mehmet Ufuk</creatorcontrib><creatorcontrib>Çolakoğlu, Sena</creatorcontrib><creatorcontrib>Tüfekçi, Ahmet</creatorcontrib><creatorcontrib>Bakar, Mustafa</creatorcontrib><creatorcontrib>Nazlıel, Bijrn</creatorcontrib><creatorcontrib>Taşçılar, Nida</creatorcontrib><creatorcontrib>Göksan, Baki</creatorcontrib><creatorcontrib>Kozak, Hasan Hüseyin</creatorcontrib><creatorcontrib>Mısırlı, Handan</creatorcontrib><creatorcontrib>Küçükoğlu, Hayriye</creatorcontrib><creatorcontrib>Midi, İpek</creatorcontrib><creatorcontrib>Mengüllüoğlu, Necdet</creatorcontrib><creatorcontrib>Aytaç, Emrah</creatorcontrib><creatorcontrib>Yeşilot, Nilüfer</creatorcontrib><creatorcontrib>İnce, Birsen</creatorcontrib><creatorcontrib>Yalın, Osman Özgür</creatorcontrib><creatorcontrib>Güneş, Taşkın</creatorcontrib><creatorcontrib>Oruç, Serdar</creatorcontrib><creatorcontrib>Mayda Domaç, Füsun</creatorcontrib><creatorcontrib>Öztürk, Şerefnur</creatorcontrib><creatorcontrib>Karahan, Ali</creatorcontrib><creatorcontrib>Erdoğan, Hacı Ali</creatorcontrib><creatorcontrib>Afşar, Nazire</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duman, Taşkın</au><au>Yayla, Vildan</au><au>Uludüz, Derya</au><au>Özaydın Göksu, Eylem</au><au>Yürekli, Vedat Ali</au><au>Genç, Hamit</au><au>Utku, Uygar</au><au>Çınar, Nilgün</au><au>Tekeli, Hakan</au><au>Sungur, Mehmet Ali</au><au>Tokuç, Firdevs Ezgi</au><au>Uzuner, Nevzat</au><au>Şenol, Mehmet Güney</au><au>Yılmaz, Arda</au><au>Gökçe, Mustafa</au><au>Demirci, Seden</au><au>Küsbeci, Özge Yılmaz</au><au>Uzuner, Gülnur Tekgöl</au><au>Şahin, Şevki</au><au>Batur Çağlayan, Hale Zeynep</au><au>Açıkgöz, Mustafa</au><au>Özdağ, Fatih</au><au>Baybaş, Sevim</au><au>Ekmekçi, Hakan</au><au>Çabalar, Murat</au><au>Yaman, Mehmet</au><au>Bektaş, Hesna</au><au>Kaplan, Yüksel</au><au>Göksel, Başak Karakurum</au><au>Milanlıoğlu, Aysel</au><au>Necioğlu Örken, Dilek</au><au>Aluçlu, Mehmet Ufuk</au><au>Çolakoğlu, Sena</au><au>Tüfekçi, Ahmet</au><au>Bakar, Mustafa</au><au>Nazlıel, Bijrn</au><au>Taşçılar, Nida</au><au>Göksan, Baki</au><au>Kozak, Hasan Hüseyin</au><au>Mısırlı, Handan</au><au>Küçükoğlu, Hayriye</au><au>Midi, İpek</au><au>Mengüllüoğlu, Necdet</au><au>Aytaç, Emrah</au><au>Yeşilot, Nilüfer</au><au>İnce, Birsen</au><au>Yalın, Osman Özgür</au><au>Güneş, Taşkın</au><au>Oruç, Serdar</au><au>Mayda Domaç, Füsun</au><au>Öztürk, Şerefnur</au><au>Karahan, Ali</au><au>Erdoğan, Hacı Ali</au><au>Afşar, Nazire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Patients with Intracerebral Hemorrhage or Hemorrhagic Transformation in the VENOST Study</atitle><jtitle>European neurology</jtitle><addtitle>Eur Neurol</addtitle><date>2020</date><risdate>2020</risdate><volume>83</volume><issue>6</issue><spage>615</spage><epage>621</epage><pages>615-621</pages><issn>0014-3022</issn><eissn>1421-9913</eissn><abstract>Introduction: Cerebral venous and sinus thrombosis (CVST) may lead to cerebral edema and increased intracranial pressure; besides, ischemic or hemorrhagic lesions may develop. Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the cerebral hemorrhage (CH) group and the CVST group. Materials and Methods: In the VENOST study, medical records of 1,193 patients with CVST, aged over 18 years, were obtained from 35 national stroke centers. Demographic characteristics, clinical symptoms, signs at the admission, radiological findings, etiologic factors, acute and maintenance treatment, and outcome results were reported. The number of involved sinuses or veins, localizations of thrombus, and lesions on CT and MRI scans were recorded. Results: CH was detected in the brain imaging of 241 (21.1%) patients, as hemorrhagic infarction in 198 patients and intracerebral hemorrhage in 43 patients. Gynecologic causes comprised the largest percentage (41.7%) of etiology and risk factors in the CVST group. In the CH group, headache associated with other neurological symptoms was more frequent. These neurological symptoms were epileptic seizures (46.9%), nausea and/or vomiting (36.5%), altered consciousness (36.5%), and focal neurological deficits (33.6%). mRS was ≥3 in 23.1% of the patients in the CH group. Discussion and Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome.</abstract><cop>Basel, Switzerland</cop><pmid>33130674</pmid><doi>10.1159/000510627</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4961-4332</orcidid><orcidid>https://orcid.org/0000-0001-5876-8643</orcidid></addata></record>
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identifier ISSN: 0014-3022
ispartof European neurology, 2020, Vol.83 (6), p.615-621
issn 0014-3022
1421-9913
language eng
recordid cdi_karger_primary_510627
source Karger Journals; MEDLINE
subjects Adolescent
Adult
Aged
Cerebral Hemorrhage - epidemiology
Cerebral Hemorrhage - etiology
Clinical Neurology: Research Article
Female
Humans
Male
Middle Aged
Retrospective Studies
Risk Factors
Sinus Thrombosis, Intracranial - complications
Sinus Thrombosis, Intracranial - diagnosis
Young Adult
title Assessment of Patients with Intracerebral Hemorrhage or Hemorrhagic Transformation in the VENOST Study
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