In vitro Models of a Three-Drug Regimen (Epirubicin, Cisplatin and Fluorouracil) for the Treatment of Colorectal Cancer

The activity of epirubicin, cisplatin and 5-fluorouracil (5-FU), as single agents or in combination (ECF), was investigated in three human colon cancer cell lines by two different assays (cell-counting assay and sulforhodamine B assay) in vitro. 5-FU was tested with both short and continuous exposur...

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Veröffentlicht in:Chemotherapy (Basel) 2001-12, Vol.47 (6), p.430-437
Hauptverfasser: Caliò, Elisabetta, Seminara, Patrizia, Aronne, Teresa, Sbaffi, Enrico, Pagani Guazzugli Bonaiuti, Valerio, Gargano, Letizia, Franchi, Fabrizio
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Sprache:eng
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Zusammenfassung:The activity of epirubicin, cisplatin and 5-fluorouracil (5-FU), as single agents or in combination (ECF), was investigated in three human colon cancer cell lines by two different assays (cell-counting assay and sulforhodamine B assay) in vitro. 5-FU was tested with both short and continuous exposure. Particular interest was focused on the results obtained in the HCT8-FU cell line, a subline with experimentally induced resistance to 5-FU. The positive modulation of both cisplatin and epirubicin cytotoxicity by 5-FU makes the ECF regimen an attractive protocol for combination therapy in colorectal cancer.
ISSN:0009-3157
1421-9794
DOI:10.1159/000048554