Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review

Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review

Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchron...

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Veröffentlicht in:Case reports in oncology 2017-01, Vol.10 (1), p.66-76
Hauptverfasser: Rochigneux, Philippe, Mescam-Mancini, Lénaig, Perrot, Delphine, Bories, Erwan, Moureau-Zabotto, Laurence, Sarran, Anthony, Guiramand, Jérôme, Bertucci, François
Format: Artikel
Sprache:eng
Schlagworte:
Abdomen
Bone metastases
Cancer
Case Report
Case reports
Endoscopy
Gastrointestinal cancer
Gastrointestinal stromal tumours
Glycoproteins
Imatinib
Inhibitor drugs
Life Sciences
Liver
Medical imaging
Metastasis
Morphology
Mutation
NMR
Nuclear magnetic resonance
Pain
Targeted cancer therapy
Tumors
Tyrosine kinase inhibitors
Ultrasonic imaging
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Zusammenfassung:Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a KIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.
ISSN:1662-6575
1662-6575
DOI:10.1159/000455188