Concurrent Gastric Adenocarcinoma of Fundic Gland Type and Carcinoma with Lymphoid Stroma: A Rare Case Report
Both gastric adenocarcinoma of fundic gland type (ADC-FG) and carcinoma with lymphoid stroma (lymphoepithelioma-like carcinoma, LELC) are relatively rare. Epstein-Barr virus (EBV) has been implicated in the pathogenesis of LELC. However, the pathogenesis of ADC-FG, as well as the role of EBV in the...
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description | Both gastric adenocarcinoma of fundic gland type (ADC-FG) and carcinoma with lymphoid stroma (lymphoepithelioma-like carcinoma, LELC) are relatively rare. Epstein-Barr virus (EBV) has been implicated in the pathogenesis of LELC. However, the pathogenesis of ADC-FG, as well as the role of EBV in the carcinogenesis of LELC, remain unclear and under debate. The current study presents a case of concurrent ADC-FG and LELC in the stomach in a 69-year-old man. Total gastrectomy was performed, and two separate masses were identified. Upon histological and immunohistochemical examination, the mass located in the lower body was determined to be LELC and the mass in the upper body was diagnosed as ADC-FG. The lesions were characterized by different mucin phenotypes and EBV in situ results. In the lower-body mass, EBV in situ hybridization expression was diffusely strongly positive, but MUC2, MUC5AC, MUC6, and CD10 were all negative. On the other hand, in the upper-body mass, the results were positive for MUC6 but negative for MUC2, MUC5AC, CD10, and EBV by in situ hybridization. The remaining gastric tissue was unremarkable, and perigastric lymph node metastases were absent. Seven months after the gastrectomy, a postoperative computed tomography scan revealed no recurrence or metastasis. |
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Epstein-Barr virus (EBV) has been implicated in the pathogenesis of LELC. However, the pathogenesis of ADC-FG, as well as the role of EBV in the carcinogenesis of LELC, remain unclear and under debate. The current study presents a case of concurrent ADC-FG and LELC in the stomach in a 69-year-old man. Total gastrectomy was performed, and two separate masses were identified. Upon histological and immunohistochemical examination, the mass located in the lower body was determined to be LELC and the mass in the upper body was diagnosed as ADC-FG. The lesions were characterized by different mucin phenotypes and EBV in situ results. In the lower-body mass, EBV in situ hybridization expression was diffusely strongly positive, but MUC2, MUC5AC, MUC6, and CD10 were all negative. On the other hand, in the upper-body mass, the results were positive for MUC6 but negative for MUC2, MUC5AC, CD10, and EBV by in situ hybridization. The remaining gastric tissue was unremarkable, and perigastric lymph node metastases were absent. Seven months after the gastrectomy, a postoperative computed tomography scan revealed no recurrence or metastasis.</description><identifier>ISSN: 1662-0631</identifier><identifier>EISSN: 1662-0631</identifier><identifier>DOI: 10.1159/000444277</identifier><identifier>PMID: 27462199</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adenocarcinoma of fundic gland type ; Carcinoma with lymphoid stroma ; Case Report ; Stomach</subject><ispartof>Case reports in gastroenterology, 2016-06, Vol.10 (2), p.292-301</ispartof><rights>2016 The Author(s). Published by S. Karger AG, Basel</rights><rights>Copyright © 2016 by S. Karger AG, Basel 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3727-70012549e61dfddf92a70ec17169bd319396707ba50f9c33efdac2d5b16778353</citedby><orcidid>0000-0002-7317-324X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939682/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939682/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27635,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27462199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cha, Hee Jeong</creatorcontrib><creatorcontrib>Kim, Kyungbin</creatorcontrib><creatorcontrib>Kim, Misung</creatorcontrib><creatorcontrib>Choi, Hyejeong</creatorcontrib><creatorcontrib>Kim, Young Min</creatorcontrib><creatorcontrib>Suh, Jae Hee</creatorcontrib><title>Concurrent Gastric Adenocarcinoma of Fundic Gland Type and Carcinoma with Lymphoid Stroma: A Rare Case Report</title><title>Case reports in gastroenterology</title><addtitle>Case Rep Gastroenterol</addtitle><description>Both gastric adenocarcinoma of fundic gland type (ADC-FG) and carcinoma with lymphoid stroma (lymphoepithelioma-like carcinoma, LELC) are relatively rare. Epstein-Barr virus (EBV) has been implicated in the pathogenesis of LELC. However, the pathogenesis of ADC-FG, as well as the role of EBV in the carcinogenesis of LELC, remain unclear and under debate. The current study presents a case of concurrent ADC-FG and LELC in the stomach in a 69-year-old man. Total gastrectomy was performed, and two separate masses were identified. Upon histological and immunohistochemical examination, the mass located in the lower body was determined to be LELC and the mass in the upper body was diagnosed as ADC-FG. The lesions were characterized by different mucin phenotypes and EBV in situ results. In the lower-body mass, EBV in situ hybridization expression was diffusely strongly positive, but MUC2, MUC5AC, MUC6, and CD10 were all negative. On the other hand, in the upper-body mass, the results were positive for MUC6 but negative for MUC2, MUC5AC, CD10, and EBV by in situ hybridization. The remaining gastric tissue was unremarkable, and perigastric lymph node metastases were absent. Seven months after the gastrectomy, a postoperative computed tomography scan revealed no recurrence or metastasis.</description><subject>Adenocarcinoma of fundic gland type</subject><subject>Carcinoma with lymphoid stroma</subject><subject>Case Report</subject><subject>Stomach</subject><issn>1662-0631</issn><issn>1662-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>DOA</sourceid><recordid>eNptkc9r2zAUx8XoWLtuh95LEfS0Q7anH5aiHgrBrFkhMMi6s5D15MRtbBnZ6ch_P2feTAs76fHe530k9CXkgsFnxjLzBQCklFzrN-SMKcVnoAQ7eVGfkvdd9wigJBfsHTnlWirOjDkjdR4bv08pND1duq5PlacLDE30LvmqibWjsaR3-waHwXLnGqQPhzbQY5FPyK-q39LVoW63sUL6o09D84Yu6NqlMGBdoOvQxtR_IG9Lt-vCx7_nOfl59_Uh_zZbfV_e54vVzAvN9UwDMJ5JExTDErE03GkInmmmTIGCGWGUBl24DErjhQglOs8xK5jSei4ycU7uRy9G92jbVNUuHWx0lf3TiGljXeorvws2A2kYFkEXgDLz3M3nwJn2yBChQD-4bkdXuy_qgH74qeR2r6SvJ021tZv4bOXxmXM-CD6NAp9i16VQTrsM7DE_O-U3sFcvL5vIf4ENwOUIPLm0CWkCpv3r_47z9XIkbIul-A3Lu6rZ</recordid><startdate>20160614</startdate><enddate>20160614</enddate><creator>Cha, Hee Jeong</creator><creator>Kim, Kyungbin</creator><creator>Kim, Misung</creator><creator>Choi, Hyejeong</creator><creator>Kim, Young Min</creator><creator>Suh, Jae Hee</creator><general>S. Karger AG</general><general>Karger Publishers</general><scope>M--</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7317-324X</orcidid></search><sort><creationdate>20160614</creationdate><title>Concurrent Gastric Adenocarcinoma of Fundic Gland Type and Carcinoma with Lymphoid Stroma: A Rare Case Report</title><author>Cha, Hee Jeong ; Kim, Kyungbin ; Kim, Misung ; Choi, Hyejeong ; Kim, Young Min ; Suh, Jae Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3727-70012549e61dfddf92a70ec17169bd319396707ba50f9c33efdac2d5b16778353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma of fundic gland type</topic><topic>Carcinoma with lymphoid stroma</topic><topic>Case Report</topic><topic>Stomach</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cha, Hee Jeong</creatorcontrib><creatorcontrib>Kim, Kyungbin</creatorcontrib><creatorcontrib>Kim, Misung</creatorcontrib><creatorcontrib>Choi, Hyejeong</creatorcontrib><creatorcontrib>Kim, Young Min</creatorcontrib><creatorcontrib>Suh, Jae Hee</creatorcontrib><collection>Karger Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Case reports in gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cha, Hee Jeong</au><au>Kim, Kyungbin</au><au>Kim, Misung</au><au>Choi, Hyejeong</au><au>Kim, Young Min</au><au>Suh, Jae Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Concurrent Gastric Adenocarcinoma of Fundic Gland Type and Carcinoma with Lymphoid Stroma: A Rare Case Report</atitle><jtitle>Case reports in gastroenterology</jtitle><addtitle>Case Rep Gastroenterol</addtitle><date>2016-06-14</date><risdate>2016</risdate><volume>10</volume><issue>2</issue><spage>292</spage><epage>301</epage><pages>292-301</pages><issn>1662-0631</issn><eissn>1662-0631</eissn><abstract>Both gastric adenocarcinoma of fundic gland type (ADC-FG) and carcinoma with lymphoid stroma (lymphoepithelioma-like carcinoma, LELC) are relatively rare. Epstein-Barr virus (EBV) has been implicated in the pathogenesis of LELC. However, the pathogenesis of ADC-FG, as well as the role of EBV in the carcinogenesis of LELC, remain unclear and under debate. The current study presents a case of concurrent ADC-FG and LELC in the stomach in a 69-year-old man. Total gastrectomy was performed, and two separate masses were identified. Upon histological and immunohistochemical examination, the mass located in the lower body was determined to be LELC and the mass in the upper body was diagnosed as ADC-FG. The lesions were characterized by different mucin phenotypes and EBV in situ results. In the lower-body mass, EBV in situ hybridization expression was diffusely strongly positive, but MUC2, MUC5AC, MUC6, and CD10 were all negative. On the other hand, in the upper-body mass, the results were positive for MUC6 but negative for MUC2, MUC5AC, CD10, and EBV by in situ hybridization. The remaining gastric tissue was unremarkable, and perigastric lymph node metastases were absent. Seven months after the gastrectomy, a postoperative computed tomography scan revealed no recurrence or metastasis.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>27462199</pmid><doi>10.1159/000444277</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7317-324X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adenocarcinoma of fundic gland type Carcinoma with lymphoid stroma Case Report Stomach |
title | Concurrent Gastric Adenocarcinoma of Fundic Gland Type and Carcinoma with Lymphoid Stroma: A Rare Case Report |
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