Merkel Cell Carcinoma: Differences between Sun-Exposed and Non-Sun-Exposed Variants - A Clinical Analysis of 36 Cases

Merkel Cell Carcinoma: Differences between Sun-Exposed and Non-Sun-Exposed Variants - A Clinical Analysis of 36 Cases

Background: There are few studies focusing on the clinical characteristics of Merkel cell carcinoma (MCC). Objective: To retrospectively analyze the clinical features of our patients and their relationship with sun exposure. Methods: Thirty-six patients diagnosed with MCC (20 men and 16 women, mean...

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Veröffentlicht in:Dermatology (Basel) 2014-01, Vol.229 (3), p.205-209
Hauptverfasser: Marcoval, Joaquim, Ferreres, Josep Ramon, Penín, Rosa María, Pérez, Diana, Viñals, Joan Maria
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Analysis
Biopsy, Needle
Carcinoma, Merkel Cell - mortality
Carcinoma, Merkel Cell - pathology
Carcinoma, Merkel Cell - surgery
Cohort Studies
Disease-Free Survival
Female
Hospitals, University
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Invasiveness - pathology
Neoplasm Staging
Original Paper
Prognosis
Retrospective Studies
Risk Assessment
Skin cancer
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Spain
Sunburn & sun tanning
Sunlight - adverse effects
Survival Analysis
Treatment Outcome
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Zusammenfassung:Background: There are few studies focusing on the clinical characteristics of Merkel cell carcinoma (MCC). Objective: To retrospectively analyze the clinical features of our patients and their relationship with sun exposure. Methods: Thirty-six patients diagnosed with MCC (20 men and 16 women, mean age 72.08 years) were included in the study. Results: 21 patients developed MCC in sun-exposed skin and 15 patients in non-sun-exposed areas. MCC was >2 cm in 19 cases. Six of the 7 patients who died as a result of MCC had non-sun-exposed tumors. Only tumor size >2 cm significantly influenced survival (p = 0.033). Conclusion: Sun-exposed lesions tended to be
ISSN:1018-8665
1421-9832
DOI:10.1159/000363104