Platelet Counts in the First Seven Days of Life and Patent Ductus Arteriosus in Preterm Very Low-Birth-Weight Infants

Background: Decreased platelet number and/or function are related to patent ductus arteriosus (PDA) in mice. Whether this is also the case in human infants remains controversial. Objectives: To investigate the association between platelet count nadir within the first 7 days of life and the rate of h...

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Veröffentlicht in:	Neonatology (Basel, Switzerland) Switzerland), 2014-01, Vol.106 (3), p.188-194
Hauptverfasser:	Bas-Suárez, Maria Pilar, González-Luis, Gema Esther, Saavedra, Pedro, Villamor, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclooxygenase Inhibitors - therapeutic use Ductus Arteriosus, Patent - blood Ductus Arteriosus, Patent - diagnosis Ductus Arteriosus, Patent - drug therapy Ductus Arteriosus, Patent - physiopathology Female Gestational Age Hemodynamics Humans Infant, Newborn Infant, Premature, Diseases - blood Infant, Premature, Diseases - diagnosis Infant, Premature, Diseases - drug therapy Infant, Premature, Diseases - physiopathology Infant, Very Low Birth Weight - blood Infant, Very Low Birth Weight - physiology Male Original Paper Platelet Count Prognosis Retrospective Studies Treatment Outcome
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Zusammenfassung:	Background: Decreased platelet number and/or function are related to patent ductus arteriosus (PDA) in mice. Whether this is also the case in human infants remains controversial. Objectives: To investigate the association between platelet count nadir within the first 7 days of life and the rate of hemodynamically significant PDA (HSPDA), as well as the rate of response to the treatment with cyclooxygenase (COX) inhibitors. Methods: This is a retrospective study of a cohort of 194 very low-birth-weight (VLBW) infants (
ISSN:	1661-7800 1661-7819
DOI:	10.1159/000362432