Matrix Metalloproteinase Inhibitor COL-3 Prevents the Development of Paclitaxel-Induced Hyperalgesia in Mice

Objective: To study the potential of chemically modified tetracycline-3 (COL-3), a potent matrix metalloproteinase (MMP) inhibitor, to protect against the development of paclitaxel-induced painful neuropathy and its immunomodulatory effects. Materials and Methods: The reaction latency to thermal sti...

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Veröffentlicht in:	Medical principles and practice 2013-01, Vol.22 (1), p.35-41
Hauptverfasser:	Parvathy, Subramanian S., Masocha, Willias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - adverse effects Brain - immunology CD11b Antigen - biosynthesis Chemokines - biosynthesis Cytokines - biosynthesis Dose-Response Relationship, Drug Female Gene Expression Hyperalgesia - chemically induced Hyperalgesia - prevention & control Matrix Metalloproteinase Inhibitors - administration & dosage Matrix Metalloproteinase Inhibitors - pharmacology Mice Mice, Inbred BALB C Original Paper Paclitaxel - adverse effects Polymerase Chain Reaction Spinal Cord - immunology Spleen - immunology Tetracyclines - administration & dosage Tetracyclines - pharmacology
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