Zum Einfluss einer variierten Vitamin-B6-Versorgung auf den Vitamin-B6-Status in Feten und Reproduktionsorganen

In order to study the influence of varying vitamin B 6 intake levels on the reproductive performance and the vitamin B 6 status of fetuses and reproductive organs, 30 pregnant rats (Sprague Dawley strain) were fed a semisynthetic casein diet supplemented with 1,6, 12, 24 and 48 mg vitamin B 6 /kg throughout pregnancy. On days 19 of pregnancy the rats were killed. Fetuses, placenta, amniotic fluid, amnion, uterus and mammary gland were analysed microbiologically for their vitamin B6 content. Reproductive performance was not influenced by the dietary treatment. Vitamin B 6 concentrations in fetuses, placenta and amniotic fluid of mothers treated with the low 1-ppm vitamin B 6 diet were significantly decreased. At a vitamin B 6 supply of 6 ppm, however, tissue saturation was already reached in these organs. Accordingly, the whole vitamin B 6 retention in the reproductive product plateaued at an intake level of 6 ppm vitamin B 6 at 37 µg vitamin B 6 per animal. These results indicate therefore that a level of 6 ppm dietary vitamin B 6 is sufficient to guarantee an optimum vitamin B 6 status in the reproductive product, and higher vitamin B 6 supplementations showed no further effect on the parameters investigated.