HLA Antigens in Patients with and without a Family History of Schizophrenia
Frequencies of HLA antigens (A, B, C and DR) were studied in patients with (n = 49) and without (n = 67) a family history of schizophrenia and in controls. Among the patients with a family history of schizophrenia significant increases were found in the A3 and B5 antigens while significant decreases...
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| Veröffentlicht in: | Human heredity 1984-01, Vol.34 (5), p.291-296 |
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| container_end_page | 296 |
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| container_issue | 5 |
| container_start_page | 291 |
| container_title | Human heredity |
| container_volume | 34 |
| creator | Rudduck, Christina Franzén, Göran Löw, Bengt Rorsman, Birgitta |
| description | Frequencies of HLA antigens (A, B, C and DR) were studied in patients with (n = 49) and without (n = 67) a family history of schizophrenia and in controls. Among the patients with a family history of schizophrenia significant increases were found in the A3 and B5 antigens while significant decreases were observed for the A1, A11 and B8 antigens. In a material of schizophrenic siblings the sharing of HLA haplotypes was consistent with normal segregation. |
| doi_str_mv | 10.1159/000153482 |
| format | Article |
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Among the patients with a family history of schizophrenia significant increases were found in the A3 and B5 antigens while significant decreases were observed for the A1, A11 and B8 antigens. In a material of schizophrenic siblings the sharing of HLA haplotypes was consistent with normal segregation.</description><identifier>ISSN: 0001-5652</identifier><identifier>EISSN: 1423-0062</identifier><identifier>DOI: 10.1159/000153482</identifier><identifier>PMID: 6592138</identifier><identifier>CODEN: HUHEAS</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger</publisher><subject>Adult and adolescent clinical studies ; Biological and medical sciences ; Gene Frequency ; Histocompatibility Antigens Class II - genetics ; HLA Antigens - genetics ; HLA-A Antigens ; HLA-B Antigens ; HLA-C Antigens ; HLA-DR Antigens ; Humans ; Medical sciences ; Original Paper ; Original Papers ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Among the patients with a family history of schizophrenia significant increases were found in the A3 and B5 antigens while significant decreases were observed for the A1, A11 and B8 antigens. In a material of schizophrenic siblings the sharing of HLA haplotypes was consistent with normal segregation.</description><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Gene Frequency</subject><subject>Histocompatibility Antigens Class II - genetics</subject><subject>HLA Antigens - genetics</subject><subject>HLA-A Antigens</subject><subject>HLA-B Antigens</subject><subject>HLA-C Antigens</subject><subject>HLA-DR Antigens</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Original Paper</subject><subject>Original Papers</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - immunology</subject><issn>0001-5652</issn><issn>1423-0062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtrGzEUhUVJcdyki-4bELQUspjm6mlpaULcCTGkkGQ93MhSrGQ840pjgvPrO47NLEpX93E-7uMQ8oXBT8aUvQAApoQ0_AMZM8lFAaD5ERnv-oXSih-TTzk_96WBiRiRkVaWM2HG5KacT-m06eKTbzKNDf2NXfRNl-lr7JYUm8V70m46inSGq1hvaRlz16YtbQO9c8v41q6XyTcRT8nHgHX2nw_xhDzMru4vy2J---v6cjovnDDQFSHoAJYHxkAuvNZKGY5gcYJSTJA9MvCgDHpjJkwjCiONlU447Yy1inNxQn7s565T-2fjc1etYna-rrHx7SZXhnFpDOgePN-DLrU5Jx-qdYorTNuKQbUzrhqM69mzw9DN48ovBvLgVK9_P-iYHdYhYeNiHjDbfwRW9Ni3PfaC6cmnQS_Lq_2iar0IPfX1v9S_tzzvjB5UqRgwI7X4C22ekO4</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Rudduck, Christina</creator><creator>Franzén, Göran</creator><creator>Löw, Bengt</creator><creator>Rorsman, Birgitta</creator><general>S. 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Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rudduck, Christina</creatorcontrib><creatorcontrib>Franzén, Göran</creatorcontrib><creatorcontrib>Löw, Bengt</creatorcontrib><creatorcontrib>Rorsman, Birgitta</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rudduck, Christina</au><au>Franzén, Göran</au><au>Löw, Bengt</au><au>Rorsman, Birgitta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA Antigens in Patients with and without a Family History of Schizophrenia</atitle><jtitle>Human heredity</jtitle><addtitle>Hum Hered</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>34</volume><issue>5</issue><spage>291</spage><epage>296</epage><pages>291-296</pages><issn>0001-5652</issn><eissn>1423-0062</eissn><coden>HUHEAS</coden><abstract>Frequencies of HLA antigens (A, B, C and DR) were studied in patients with (n = 49) and without (n = 67) a family history of schizophrenia and in controls. Among the patients with a family history of schizophrenia significant increases were found in the A3 and B5 antigens while significant decreases were observed for the A1, A11 and B8 antigens. In a material of schizophrenic siblings the sharing of HLA haplotypes was consistent with normal segregation.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger</pub><pmid>6592138</pmid><doi>10.1159/000153482</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Human heredity, 1984-01, Vol.34 (5), p.291-296 |
| issn | 0001-5652 1423-0062 |
| language | eng |
| recordid | cdi_karger_primary_153482 |
| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult and adolescent clinical studies Biological and medical sciences Gene Frequency Histocompatibility Antigens Class II - genetics HLA Antigens - genetics HLA-A Antigens HLA-B Antigens HLA-C Antigens HLA-DR Antigens Humans Medical sciences Original Paper Original Papers Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia - genetics Schizophrenia - immunology |
| title | HLA Antigens in Patients with and without a Family History of Schizophrenia |
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