HLA Antigens in Patients with and without a Family History of Schizophrenia

HLA Antigens in Patients with and without a Family History of Schizophrenia

Frequencies of HLA antigens (A, B, C and DR) were studied in patients with (n = 49) and without (n = 67) a family history of schizophrenia and in controls. Among the patients with a family history of schizophrenia significant increases were found in the A3 and B5 antigens while significant decreases...

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Veröffentlicht in:Human heredity 1984-01, Vol.34 (5), p.291-296
Hauptverfasser: Rudduck, Christina, Franzén, Göran, Löw, Bengt, Rorsman, Birgitta
Format: Artikel
Sprache:eng
Schlagworte:
Adult and adolescent clinical studies
Biological and medical sciences
Gene Frequency
Histocompatibility Antigens Class II - genetics
HLA Antigens - genetics
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
HLA-DR Antigens
Humans
Medical sciences
Original Paper
Original Papers
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia - genetics
Schizophrenia - immunology
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Zusammenfassung:Frequencies of HLA antigens (A, B, C and DR) were studied in patients with (n = 49) and without (n = 67) a family history of schizophrenia and in controls. Among the patients with a family history of schizophrenia significant increases were found in the A3 and B5 antigens while significant decreases were observed for the A1, A11 and B8 antigens. In a material of schizophrenic siblings the sharing of HLA haplotypes was consistent with normal segregation.
ISSN:0001-5652
1423-0062
DOI:10.1159/000153482