Infertility in Cryptorchidism Is Linked to the Stage of Germ Cell Development at Orchidopexy

Infertility in Cryptorchidism Is Linked to the Stage of Germ Cell Development at Orchidopexy

Background: Cryptorchidism represents the most common endocrine disease in boys, with infertility frequently observed in unilateral as well as bilateral forms. In this study, we examined the role of Ad (dark) spermatogonia for fertility in cryptorchid boys. The hypothesis to be proven was that boys...

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Veröffentlicht in:Hormone research 2007-01, Vol.68 (1), p.46-52
Hauptverfasser: Hadziselimovic, Faruk, Höcht, Burckhard, Herzog, Bruno, Buser, Mauro W.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Child
Child, Preschool
Cryptorchidism - complications
Cryptorchidism - surgery
Humans
Infant
Infertility, Male - etiology
Male
Original Paper
Sperm Count
Spermatogonia - cytology
Spermatogonia - growth & development
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Zusammenfassung:Background: Cryptorchidism represents the most common endocrine disease in boys, with infertility frequently observed in unilateral as well as bilateral forms. In this study, we examined the role of Ad (dark) spermatogonia for fertility in cryptorchid boys. The hypothesis to be proven was that boys lacking Ad spermatogonia will develop infertility despite a successful orchidopexy at an early age. Methods: To estimate total sperm count, one of the most predictive parameters of male fertility, we analyzed the ejaculatein 218 cryptorchid men and correlated it with the developmental stage of their germ cells at the time of successful surgery. Results: Abnormal sperm concentration (
ISSN:1663-2818
1663-2826
1423-0046
DOI:10.1159/000100874