Relation of Trp64Arg Polymorphism of Beta 3-Adrenergic Receptor Gene to Adipocytokines and Fat Distribution in Obese Patients

Background/Aim: Obesity has multiple causes and is determined by the interaction between genetic and environmental factors. A genetic factor is a (Trp64Arg) missense mutation in the beta 3-adrenergic receptor. The aim of our study was to investigate the influence of Trp64Arg polymorphism in the beta 3-adrenergic receptor gene on weight, adipocytokines, insulin resistance, and fat distribution in obese patients. Methods: A population of 217 nondiabetic obese Caucasian outpatients was analyzed. Indirect calorimetry and tetrapolar bioimpedance results, blood pressure, nutritional intake with 3-day food records, and biochemical parameters were evaluated. The genotype of beta 3-adrenergic receptor gene polymorphism (Trp64Arg) was studied. Results: The mean age of the patients was 44.3 ± 16.4 years, and the mean body mass index was 35.2 ± 5.2. One hundred and eighty-six patients (52 males and 134 females; 85.8%) had the genotype Trp64/Trp64 (wild-type group), and 31 patients (11 males and 20 females; 14.2%) had the genotype Trp64/Arg64 (mutant group). In the mutant group, body mass index, weight, fat mass, waist-to-hip ratio, waist circumference, and C-reactive protein levels were higher than in the wild-type group. The adipocytokine levels were similar in both groups. Conclusion: The patients of the mutant group (Trp64/Arg64) had higher body mass index, weight, waist circumference, fat mass, waist-to-hip ratio, and C-reactive protein values than those of the wild-type group.