Memory-Enhancing Effects of Secreted Forms of the β -amyloid Precursor Protein in Normal and Amnestic Mice

When administered intracerebroventricularly to mice performing various learning tasks involving either short-term or long-term memory, secreted forms of the β -amyloid precursor protein (APPs 751and APPs 695) have potent memory-enhancing effects and block learning deficits induced by scopolamine. Th...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1998-10, Vol.95 (21), p.12683-12688
Hauptverfasser: Meziane, H., J.-C. Dodart, Mathis, C., Little, S., Clemens, J., Paul, S. M., Ungerer, A.
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Sprache:eng
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Zusammenfassung:When administered intracerebroventricularly to mice performing various learning tasks involving either short-term or long-term memory, secreted forms of the β -amyloid precursor protein (APPs 751and APPs 695) have potent memory-enhancing effects and block learning deficits induced by scopolamine. The memory-enhancing effects of APPswere observed over a wide range of extremely low doses (0.05-5,000 pg intracerebroventricularly), blocked by anti-APPsantisera, and observed when APPswas administered either after the first training session in a visual discrimination or a lever-press learning task or before the acquisition trial in an object recognition task. APPshad no effect on motor performance or exploratory activity. APPs 695and APPs 751were equally effective in the object recognition task, suggesting that the memory-enhancing effect of APPsdoes not require the Kunitz protease inhibitor domain. These data suggest an important role for APPss on memory processes.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.95.21.12683