THE EFFECTS OF A SPIRONOLACTONE AND ESTROGEN IN SALT DEFICIENT RABBITS

THE EFFECTS OF A SPIRONOLACTONE AND ESTROGEN IN SALT DEFICIENT RABBITS

Male rabbits deprived of food develop a polyuric-polydipsic syndrome which is due to a renal salt loss. This syndrome is inhibited by estrogen administration. To determine whether adrenal mediation is involved in this estrogen effect, the influence of a spironolactone which blocks the peripheral act...

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Veröffentlicht in:Proceedings of the Pennsylvania Academy of Science 1966-06, Vol.39 (2), p.170-174
Hauptverfasser: Nocenti, M. R., Cizek, L. J., Aronoff, M. S., Pieri, C. M.
Format: Artikel
Sprache:eng
Schlagworte:
Body weight
Estrogens
Excretion
Food deprivation
INVESTIGATIONS IN BIOLOGICAL SCIENCES
Mineralocorticoids
Salts
Sodium
Steroids
Table salt
Urine
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Zusammenfassung:Male rabbits deprived of food develop a polyuric-polydipsic syndrome which is due to a renal salt loss. This syndrome is inhibited by estrogen administration. To determine whether adrenal mediation is involved in this estrogen effect, the influence of a spironolactone which blocks the peripheral action of aldosterone was studied. Aldactone alone caused a marked increase in sodium loss. Aldactone did not abolish the depressed fluid exchange due to estrogen administration.
ISSN:0096-9222