In vitro and in vivo Two-Photon Luminescence Imaging of Single Gold Nanorods

Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a$cos^4$dependence on the incident polarization. The TPL excitation spectrum can be superimposed onto the longitudinal plasmon band, indicating a plasmon-enhanced...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-11, Vol.102 (44), p.15752-15756
Hauptverfasser:	Haifeng Wang, Terry B. Huff, Daniel A. Zweifel, He, Wei, Low, Philip S., Alexander Wei, Cheng, Ji-Xin, Shen, Y. Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Circulation Blood Vessels Diagnostic Imaging - methods Ear - blood supply Emission spectra Female Fluorescence Polarization Gold Imaging Laser beams Luminescence Luminescent Measurements - methods Mice Mice, Inbred BALB C Microscopy, Confocal - methods Molecules Nanorods Nanostructures Nanotechnology Physical Sciences Plasmons Scientific imaging Signaling Wave excitation Wavelengths
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Zusammenfassung:	Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a$cos^4$dependence on the incident polarization. The TPL excitation spectrum can be superimposed onto the longitudinal plasmon band, indicating a plasmon-enhanced two-photon absorption cross section. The TPL signal from a single nanorod is 58 times that of the two-photon fluorescence signal from a single rhodamine molecule. The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.0504892102