Modelling the structural response of an eukaryotic cell in the optical stretcher
The cytoskeleton of an eukaryotic cell is a composite polymer material with unique structural (mechanical) properties. To investigate the role of individual cytoskeletal polymers in the deformation response of a cell to an external force (stress), we created two structural models – a thick shell mod...
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| Veröffentlicht in: | Current science (Bangalore) 2005-05, Vol.88 (9), p.1434-1440 |
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| container_title | Current science (Bangalore) |
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| creator | Ananthakrishnan, Revathi Guck, Jochen Wottawah, Falk Schinkinger, Stefan Lincoln, Bryan Romeyke, Maren Käs, Josef |
| description | The cytoskeleton of an eukaryotic cell is a composite polymer material with unique structural (mechanical) properties. To investigate the role of individual cytoskeletal polymers in the deformation response of a cell to an external force (stress), we created two structural models – a thick shell model for the actin cortex, and a three-layered model for the whole cell. These structural models for a cell are based on data obtained by deforming suspended cells, where each cell is stretched between two counter-propagating laser beams using an optical stretcher. Our models, with the data, suggest that the outer actin cortex is the main determinant of the structural response of the cell. |
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| fulltext | fulltext |
| identifier | ISSN: 0011-3891 |
| ispartof | Current science (Bangalore), 2005-05, Vol.88 (9), p.1434-1440 |
| issn | 0011-3891 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; JSTOR Archive Collection A-Z Listing |
| subjects | Actins Cell nucleus Deformation Endothelial cells Fibroblasts L cells Lasers Microtubules Modeling Stretchers |
| title | Modelling the structural response of an eukaryotic cell in the optical stretcher |
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