SYNTHESIS OF 6,8-DISUBSTITUTED-2-METHYL/PHENYL-3-[4-(3-PHTHALIMIDO ACETAMIDO/PROPIONAMIDO)]PHENYL-QUINAZOLIN-4-ONES AS ANTHELMINTIC AGENTS

SYNTHESIS OF 6,8-DISUBSTITUTED-2-METHYL/PHENYL-3-[4-(3-PHTHALIMIDO ACETAMIDO/PROPIONAMIDO)]PHENYL-QUINAZOLIN-4-ONES AS ANTHELMINTIC AGENTS

Quinazolone nucleus possesses a broad spectrum of anthelmintic activity. Certain phthalimide derivatives have also been reported to be active against helminth parasites. Attempts have been made to synthesise and evaluate the anthelmintic activity of compounds having both moieties. Various 6,8 disubs...

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Veröffentlicht in:Current science (Bangalore) 1985-11, Vol.54 (22), p.1162-1164
Hauptverfasser: SHUKLA, J. S., SRIVASTAVA, BEENA
Format: Artikel
Sprache:eng
Schlagworte:
Anthelmintics
Chlorides
Dosage
Infections
Phenyls
Phthalimides
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Zusammenfassung:Quinazolone nucleus possesses a broad spectrum of anthelmintic activity. Certain phthalimide derivatives have also been reported to be active against helminth parasites. Attempts have been made to synthesise and evaluate the anthelmintic activity of compounds having both moieties. Various 6,8 disubstituted-2-methyl/phenyl-3-[4-(3-phthalimido acetamido/propionamido]phenyl quinazolin-4-ones(V) were synthesised, by the reaction of 2-(p-amino phenyl acetamido/propionamido)phthalimide (IV) with 6,8 disubstituted-2-phenyl benzoxazin-4-one, and screened for their anthelmintic activity.
ISSN:0011-3891