apl-1, a Caenorhabditis elegans Gene Encoding a Protein Related to the Human β-Amyloid Protein Precursor

The major component of senile plaques found in the brains of Alzheimer disease patients is the β-amyloid peptide, which is derived from a larger amyloid precursor protein (APP). Recently, a number of APP and APP-related proteins have been identified in different organisms and constitute the family o...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1993-12, Vol.90 (24), p.12045-12049
Hauptverfasser: Daigle, Isabelle, Li, C.
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Sprache:eng
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Zusammenfassung:The major component of senile plaques found in the brains of Alzheimer disease patients is the β-amyloid peptide, which is derived from a larger amyloid precursor protein (APP). Recently, a number of APP and APP-related proteins have been identified in different organisms and constitute the family of APP proteins. We have isolated several cDNAs encoding an APP-related protein in the nematode Caenorhabditis elegans and have designated the corresponding gene as apl-1. The apl-1 transcripts undergo two forms of posttranscriptional modification: trans-splicing and alternative polyadenylylation. In vitro translation of an apl-1 cDNA results in a protein of approximately the expected size. Similar to the Drosophila, human, and mouse APP-related proteins, APL-1 does not appear to contain the β-amyloid peptide. Because APP-related proteins seem to be conserved through evolution, the apl-1 gene from C. elegans should be important for determining the normal function of human APP.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.90.24.12045