Single Dose Digoxin Pharmacokinetics in the Quaker Conure (Myiopsitta monachus)

The pharmacokinetic disposition of digoxin elixir was determined in 20 quaker conures (Myiopsitta monachus) following administration of a single oral dose given at 0.05 mg/kg of body weight. The plasma concentration time profile best fit a two-compartment open model with an absorption, distribution, and elimination phase. The half-life for absorption was 0.83 hr; for distribution, 1.47 hr; and for elimination, 25.86 hr. Peak plasma concentration (1.80 ± 0.36 ng/ml) was reached 1 hr postadministration; plasma concentration was below the assay sensitivity at 24 hr.