1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D$_{3}$ in the Intestine
The major polar metabolite of cholecalciferol (vitamin D$_{3}$) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C$_{27}$H$_{44}$O$_{3}$ and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produce...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1971-07, Vol.173 (3991), p.51-54 |
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| container_issue | 3991 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 173 |
| creator | Norman, Anthony W. Myrtle, James F. Midgett, Ronald J. Nowicki, Henry G. Williams, Vincent Popjak, G. |
| description | The major polar metabolite of cholecalciferol (vitamin D$_{3}$) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C$_{27}$H$_{44}$O$_{3}$ and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this laboratory) probably represents the biologically active form of cholecalciferol in the intestine. |
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This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this laboratory) probably represents the biologically active form of cholecalciferol in the intestine.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><language>eng</language><publisher>American Association for the Advancement of Science</publisher><subject>Atoms ; Calcium ; Calcium metabolism ; Cholecalciferols ; Intestines ; Kidneys ; Lipid metabolism ; Mass spectra ; Metabolites ; Oxygen</subject><ispartof>Science (American Association for the Advancement of Science), 1971-07, Vol.173 (3991), p.51-54</ispartof><rights>Copyright 1971 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1731691$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1731691$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,58017,58250</link.rule.ids></links><search><creatorcontrib>Norman, Anthony W.</creatorcontrib><creatorcontrib>Myrtle, James F.</creatorcontrib><creatorcontrib>Midgett, Ronald J.</creatorcontrib><creatorcontrib>Nowicki, Henry G.</creatorcontrib><creatorcontrib>Williams, Vincent</creatorcontrib><creatorcontrib>Popjak, G.</creatorcontrib><title>1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D$_{3}$ in the Intestine</title><title>Science (American Association for the Advancement of Science)</title><description>The major polar metabolite of cholecalciferol (vitamin D$_{3}$) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C$_{27}$H$_{44}$O$_{3}$ and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this laboratory) probably represents the biologically active form of cholecalciferol in the intestine.</description><subject>Atoms</subject><subject>Calcium</subject><subject>Calcium metabolism</subject><subject>Cholecalciferols</subject><subject>Intestines</subject><subject>Kidneys</subject><subject>Lipid metabolism</subject><subject>Mass spectra</subject><subject>Metabolites</subject><subject>Oxygen</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFyjsLwjAUhuEgCtbLP3DI4GghMVStm3jBbg7iWkJ6So-0OZIEsYj_XQV3p--F5-uwSIo0idO5UF0WCaEW8Uoskz4beH8V4mOpilgjZ_Mk3mHVFo4eramoBqNrgyU4qtc8K8AGLNHogGQ5lTxUwE-ObuSh4BsT8A78QK752gWDbtDy3TR_qteUf_J7z2wAH9DCiPVKXXsY_3bIJof9eXuMrz6Qy28OG-3aXC6VXKRS_eE3U2RE4g</recordid><startdate>19710702</startdate><enddate>19710702</enddate><creator>Norman, Anthony W.</creator><creator>Myrtle, James F.</creator><creator>Midgett, Ronald J.</creator><creator>Nowicki, Henry G.</creator><creator>Williams, Vincent</creator><creator>Popjak, G.</creator><general>American Association for the Advancement of Science</general><scope/></search><sort><creationdate>19710702</creationdate><title>1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D$_{3}$ in the Intestine</title><author>Norman, Anthony W. ; Myrtle, James F. ; Midgett, Ronald J. ; Nowicki, Henry G. ; Williams, Vincent ; Popjak, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-jstor_primary_17316913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Atoms</topic><topic>Calcium</topic><topic>Calcium metabolism</topic><topic>Cholecalciferols</topic><topic>Intestines</topic><topic>Kidneys</topic><topic>Lipid metabolism</topic><topic>Mass spectra</topic><topic>Metabolites</topic><topic>Oxygen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norman, Anthony W.</creatorcontrib><creatorcontrib>Myrtle, James F.</creatorcontrib><creatorcontrib>Midgett, Ronald J.</creatorcontrib><creatorcontrib>Nowicki, Henry G.</creatorcontrib><creatorcontrib>Williams, Vincent</creatorcontrib><creatorcontrib>Popjak, G.</creatorcontrib><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norman, Anthony W.</au><au>Myrtle, James F.</au><au>Midgett, Ronald J.</au><au>Nowicki, Henry G.</au><au>Williams, Vincent</au><au>Popjak, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D$_{3}$ in the Intestine</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><date>1971-07-02</date><risdate>1971</risdate><volume>173</volume><issue>3991</issue><spage>51</spage><epage>54</epage><pages>51-54</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>The major polar metabolite of cholecalciferol (vitamin D$_{3}$) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C$_{27}$H$_{44}$O$_{3}$ and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this laboratory) probably represents the biologically active form of cholecalciferol in the intestine.</abstract><pub>American Association for the Advancement of Science</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1971-07, Vol.173 (3991), p.51-54 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_jstor_primary_1731691 |
| source | JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Atoms Calcium Calcium metabolism Cholecalciferols Intestines Kidneys Lipid metabolism Mass spectra Metabolites Oxygen |
| title | 1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D$_{3}$ in the Intestine |
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