1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D$_{3}$ in the Intestine

The major polar metabolite of cholecalciferol (vitamin D$_{3}$) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C$_{27}$H$_{44}$O$_{3}$ and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produce...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1971-07, Vol.173 (3991), p.51-54
Hauptverfasser: Norman, Anthony W., Myrtle, James F., Midgett, Ronald J., Nowicki, Henry G., Williams, Vincent, Popjak, G.
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Sprache:eng
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Zusammenfassung:The major polar metabolite of cholecalciferol (vitamin D$_{3}$) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C$_{27}$H$_{44}$O$_{3}$ and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this laboratory) probably represents the biologically active form of cholecalciferol in the intestine.
ISSN:0036-8075
1095-9203