Nanofilaments on glioblastoma exosomes revealed by peak force microscopy
Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofi...
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| Veröffentlicht in: | Journal of the Royal Society interface 2014-03, Vol.11 (92), p.20131150-20131150 |
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| container_end_page | 20131150 |
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| container_issue | 92 |
| container_start_page | 20131150 |
| container_title | Journal of the Royal Society interface |
| container_volume | 11 |
| creator | Sharma, Shivani Das, Kingshuk Woo, JungReem Gimzewski, James K. |
| description | Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication. |
| doi_str_mv | 10.1098/rsif.2013.1150 |
| format | Article |
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We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. 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R. Soc. Interface</stitle><addtitle>J. R. Soc. Interface</addtitle><date>2014-03-06</date><risdate>2014</risdate><volume>11</volume><issue>92</issue><spage>20131150</spage><epage>20131150</epage><pages>20131150-20131150</pages><issn>1742-5689</issn><eissn>1742-5662</eissn><abstract>Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication.</abstract><cop>England</cop><pub>The Royal Society</pub><pmid>24402921</pmid><doi>10.1098/rsif.2013.1150</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1742-5689 |
| ispartof | Journal of the Royal Society interface, 2014-03, Vol.11 (92), p.20131150-20131150 |
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| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Biomechanical Phenomena Biophysics Cell Communication - physiology Cell Line, Tumor Cytoskeleton - ultrastructure Exosomes - metabolism Exosomes - ultrastructure Glioblastoma - metabolism Glioblastoma - physiopathology Glioblastoma Exosomes Humans Intercellular Communication Microscopy, Atomic Force - methods Models, Biological Nanofilaments Nanoparticles Nanotechnology |
| title | Nanofilaments on glioblastoma exosomes revealed by peak force microscopy |
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