Nanofilaments on glioblastoma exosomes revealed by peak force microscopy

Nanofilaments on glioblastoma exosomes revealed by peak force microscopy

Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofi...

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Veröffentlicht in:Journal of the Royal Society interface 2014-03, Vol.11 (92), p.20131150-20131150
Hauptverfasser: Sharma, Shivani, Das, Kingshuk, Woo, JungReem, Gimzewski, James K.
Format: Artikel
Sprache:eng
Schlagworte:
Biomechanical Phenomena
Biophysics
Cell Communication - physiology
Cell Line, Tumor
Cytoskeleton - ultrastructure
Exosomes - metabolism
Exosomes - ultrastructure
Glioblastoma - metabolism
Glioblastoma - physiopathology
Glioblastoma Exosomes
Humans
Intercellular Communication
Microscopy, Atomic Force - methods
Models, Biological
Nanofilaments
Nanoparticles
Nanotechnology
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Beschreibung
Zusammenfassung:Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication.
ISSN:1742-5689
1742-5662
DOI:10.1098/rsif.2013.1150