Synthesis of 10,11-Dihydro-12-oxo-LTB4, a Key Biochemical Intermediate

Synthesis of 10,11-Dihydro-12-oxo-LTB4, a Key Biochemical Intermediate

The first total synthesis of the 5(S)-hydroxy-10,11-dihydro-12-oxo-6(Z),8(E),14(Z)-eicosatrienoic acid (10,11-dihydro-12-oxo-LTB4) (3) is reported. This compound is a key pivotal intermediate in the biotransformation of LTB4 by the so-called “LTB4 reductase pathway”.

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Veröffentlicht in:Journal of organic chemistry 1997-01, Vol.62 (2), p.325-330
Hauptverfasser: Khanapure, Subhash P, Wang, Steven S, Powell, William S, Rokach, Joshua
Format: Artikel
Sprache:eng
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Zusammenfassung:The first total synthesis of the 5(S)-hydroxy-10,11-dihydro-12-oxo-6(Z),8(E),14(Z)-eicosatrienoic acid (10,11-dihydro-12-oxo-LTB4) (3) is reported. This compound is a key pivotal intermediate in the biotransformation of LTB4 by the so-called “LTB4 reductase pathway”.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo9614957