Dialkylformamldines: depurination resistant N6-protecting group for deoxyadenosine

Dialkylformamldines: depurination resistant N6-protecting group for deoxyadenosine

Sterically hindered N6-dialkylformamid1ne protected deoxyadenosine 1s more stable to acidic depuMnation than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligo-nucleotides.

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Veröffentlicht in:Nucleic acids research 1983-11, Vol.11 (22), p.8031-8036
Hauptverfasser: Froehler, B.C., Matteucci, M.D.
Format: Artikel
Sprache:eng
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Zusammenfassung:Sterically hindered N6-dialkylformamid1ne protected deoxyadenosine 1s more stable to acidic depuMnation than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligo-nucleotides.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/11.22.8031