Enhanced Production of Mouse Mammary Tumor Virus in DexamethasoneTreated, 5-Iododeoxyuridine-Stimulated Mammary Tumor Cell Cultures

Enhanced Production of Mouse Mammary Tumor Virus in DexamethasoneTreated, 5-Iododeoxyuridine-Stimulated Mammary Tumor Cell Cultures

The production of virus-related RNA-dependent DNA polymerase, cell-associated mouse mammary tumor virus (MMTV) antigens, and B particles by 5-iododeoxyuridine in C3H mouse mammary tumor cell cultures was enhanced by dexamethasone, a synthetic glucocorticoid hormone. This enhancement further implicat...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1974-06, Vol.52 (6), p.1881-1886
Hauptverfasser: Fine, Donald L., Plowman, Jonathan K., Kelley, Susan P., Arthur, Larry O., Hillman, Elizabeth A.
Format: Artikel
Sprache:eng
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Zusammenfassung:The production of virus-related RNA-dependent DNA polymerase, cell-associated mouse mammary tumor virus (MMTV) antigens, and B particles by 5-iododeoxyuridine in C3H mouse mammary tumor cell cultures was enhanced by dexamethasone, a synthetic glucocorticoid hormone. This enhancement further implicates hormones in MMTV replication and provides the basis for an in vitro MMTV production system.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/52.6.1881