Experimental T-2 Toxicosis in Swine

Experimental T-2 Toxicosis in Swine. I. Changes in Cardiac Output, Aortic Mean Pressure, Catecholamines, 6-Keto-PGF1α, Thromboxane B2, and Acid-Base Parameters. LORENZANA, R. M., BEASLEY, V. R., BUCK, W. B., GHENT, A. W., LUNDEEN, G. R., AND POPPENGA, R. H. (1985). Fundam. Appl. Toxicol.. 5,879-892. T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1α, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.