Isolation and Characterization of a Trisiallactosylceramide, GT3, Containing an O-Acetylated Silaic Acid in Cod Fish Brain

Isolation and Characterization of a Trisiallactosylceramide, GT3, Containing an O-Acetylated Silaic Acid in Cod Fish Brain

An O-acetylated ganglioside that generated a trisialyllactosylceramide or GT3 by base treatment was found for the first time in cod fish brain. This ganglioside was isolated by high-performance liquid chromatography, and characterized by fast atom bombardment mass spectrometry, and proton nuclear ma...

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Veröffentlicht in:Journal of biochemistry (Tokyo) 1993-04, Vol.113 (4), p.502-507
Hauptverfasser: Waki, Hastue, Murata, Akane, Kon, Kazuo, Maruyama, Kazuaki, Kimura, Shoji, Ogura, Haruo, Ando, Susumu
Format: Artikel
Sprache:eng
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Zusammenfassung:An O-acetylated ganglioside that generated a trisialyllactosylceramide or GT3 by base treatment was found for the first time in cod fish brain. This ganglioside was isolated by high-performance liquid chromatography, and characterized by fast atom bombardment mass spectrometry, and proton nuclear magnetic resonance spectroscopy in addition to chemical analysis. The structure was identified as a modified GT3 in which the external sialic acid is O-acetylated at the C-9 position. The chemical structure is as follows: H3(9- O-Ac-NeuAc2-8NeuAc2-8NeuAc2-3)Lac Cer.
ISSN:0021-924X
DOI:10.1093/oxfordjournals.jbchem.a124073