Binding of Chemical Carcinogens to Macromolecules in Cultured Human Colon: Brief Communication

Binding of Chemical Carcinogens to Macromolecules in Cultured Human Colon: Brief Communication

Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo[a]pyrene, dimethylnitrosamine, and 1,2-dimethylhydrazlne was found In both cell DNA and protein. 1,...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1977-01, Vol.59 (2), p.351-357
Hauptverfasser: Autrup, Herman, Harris, Curtis C., Stoner, Gary D., Michael L., Jesudason, Trump, Benjamin F.
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container_end_page 357
container_issue 2
container_start_page 351
container_title JNCI : Journal of the National Cancer Institute
container_volume 59
creator Autrup, Herman
Harris, Curtis C.
Stoner, Gary D.
Michael L., Jesudason
Trump, Benjamin F.
description Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo[a]pyrene, dimethylnitrosamine, and 1,2-dimethylhydrazlne was found In both cell DNA and protein. 1,2-Dimethylhydrazlne methylated DNA at both N-7 and O-6 positions of guanine.
doi_str_mv 10.1093/jnci/59.2.351
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title Binding of Chemical Carcinogens to Macromolecules in Cultured Human Colon: Brief Communication
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