Binding of Chemical Carcinogens to Macromolecules in Cultured Human Colon: Brief Communication

Binding of Chemical Carcinogens to Macromolecules in Cultured Human Colon: Brief Communication

Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo[a]pyrene, dimethylnitrosamine, and 1,2-dimethylhydrazlne was found In both cell DNA and protein. 1,...

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Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1977-01, Vol.59 (2), p.351-357
Hauptverfasser: Autrup, Herman, Harris, Curtis C., Stoner, Gary D., Michael L., Jesudason, Trump, Benjamin F.
Format: Artikel
Sprache:eng
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Zusammenfassung:Metabolic activation of different chemical classes of carcinogens was studied in cultured human colon epithelia. Human colon epithelia were maintained in explant culture up to 4 days. Binding of benzo[a]pyrene, dimethylnitrosamine, and 1,2-dimethylhydrazlne was found In both cell DNA and protein. 1,2-Dimethylhydrazlne methylated DNA at both N-7 and O-6 positions of guanine.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/59.2.351