Concurrent Oral 9 – Rheumatoid Arthritis: Aetiopathogenesis [OP59–OP64]

Concurrent Oral 9 – Rheumatoid Arthritis: Aetiopathogenesis [OP59–OP64]

Background: Interleukin (IL)-17 is the main Th-1 cytokine, produced by activated T-lymphocytes. The potential IL-17 value in rheumatoid arthritis (RA) pathogenesis consists of its independent inflammatory response induction and mediated stimulation of proinflammatory factors synthesis resulting in j...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 2010-04, Vol.49 (suppl-1), p.i26-i28
Hauptverfasser: Biliavska, Iuliia V., Bortkevych, Oleg P., Ceeraz, Sabrina, Spencer, Jo, Choy, Ernest H., Corrigall, Valerie, Bombardieri, Michele, Ngar Woon Kam, Yvonne, Brentano, Fabia, Choi, Ken, Kyburz, Diego, Gay, Steffen, McInnes, Iain B., Pitzalis, Costantino, Gompels, Luke L., Vincent, Tonia, Madden, Leigh, Lim, Ngee H., McConnell, Ellen, Mcnamee, Kay, Haskard, Dorian O., Paleolog, Ewa M., Swales, Catherine, Mahoney, David J., Athanasou, Nicholas A., Sharif, Omar, Day, Anthony J., Milner, Caroline M., Sabokbar, Afsie, Knowles, Helen, Cleton-Jansen, Anne-Marie, Korsching, Eberhard, Athanasou, Nick
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Sprache:eng
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Zusammenfassung:Background: Interleukin (IL)-17 is the main Th-1 cytokine, produced by activated T-lymphocytes. The potential IL-17 value in rheumatoid arthritis (RA) pathogenesis consists of its independent inflammatory response induction and mediated stimulation of proinflammatory factors synthesis resulting in joint destruction. The aim of study was to determine the role of IL-17 in immuno-inflammatory/autoimmune reactions development and to reveal IL-17 serum level associations with clinical and immunological characteristics of RA. Methods: 50 patients with early RA (disease duration
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keq709