Remote measurement of urinary radioactivity in 18F-FDG PET patients using Compton camera for accuracy evaluation of standardized uptake value

Currently, the most commonly used estimate of metabolic activity during clinical positron emission tomography (PET) is standardized uptake value (SUV) obtained from 18F-fluorodeoxyglucose (18F-FDG) captured in cancer cells. Although SUV is evaluated after corrections for the injected dose, weight, and other such parameters, the entire injected dose is inappropriate for this calculation because some FDG is excreted in urine. Therefore, the injected dose warrants correction by assessment of urinary radioactivity in patients before PET to enhance the accuracy of FDG calculation. However, this is not typically performed in clinical practice owing to secondary effects of radioactive contamination in hospitals and radiation exposure risk to the attending staff. Therefore, we aimed to develop a remote method for the measurement of urinary radioactivity in FDG-PET patients. Urinary radioactivity was estimated in a toilet bowl using gamma-ray distribution obtained with a Compton camera. The gamma-ray events from the toilet bowl per unit time (5 s) facilitated radioactivity calculation. Between 0 and 40 MBq, deviation of our detector from the linearity for radioactivity was