Closed-loop system to enhance slow-wave activity
Objective. Recent evidence reports cognitive, metabolic, and sleep restoration benefits resulting from the enhancement of sleep slow-waves using auditory stimulation. Our objective is to make this concept practical for consumer use by developing and validating an electroencephalogram (EEG) closed-lo...
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Veröffentlicht in: | Journal of neural engineering 2018-12, Vol.15 (6), p.066018-066018 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Objective. Recent evidence reports cognitive, metabolic, and sleep restoration benefits resulting from the enhancement of sleep slow-waves using auditory stimulation. Our objective is to make this concept practical for consumer use by developing and validating an electroencephalogram (EEG) closed-loop system to deliver auditory stimulation during sleep to enhance slow-waves. Approach. The system automatically detects slow-wave sleep with 74% sensitivity and 97% specificity and optimally delivers stimulation in the form of 50 ms-long tones separated by a constant one-second inter-tone interval at a volume that is dynamically modulated such that louder tones are delivered when sleep is deeper. The system was tested in a study involving 28 participants (18F, 10M; 36.9 ± 7.3 years old; median age: 40 years old) who used the system for ten nights (five nights in a sham condition and five in a stimulation condition). Four nights in each condition were recorded at-home and the fifth one in-lab. Main results. The analysis in two age groups defined by the median age of participants in the study shows significant slow wave activity enhancement (+16.1%, p |
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ISSN: | 1741-2560 1741-2552 |
DOI: | 10.1088/1741-2552/aae18f |