Pulsed low dose-rate radiotherapy: radiobiology and dosimetry
Pulsed low dose-rate radiotherapy (PLDR) relies on two radiobiological findings, the hyper-radiosensitivity of tumor cells at small doses and the reduced normal tissue toxicity at low dose rates. This is achieved by delivering the daily radiation dose of 2 Gy in 10 sub-fractions (pulses) with a 3 mi...
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| Veröffentlicht in: | Physics in medicine & biology 2022-01, Vol.67 (3), p.3 |
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| creator | Ma, C M Charlie |
| description | Pulsed low dose-rate radiotherapy (PLDR) relies on two radiobiological findings, the hyper-radiosensitivity of tumor cells at small doses and the reduced normal tissue toxicity at low dose rates. This is achieved by delivering the daily radiation dose of 2 Gy in 10 sub-fractions (pulses) with a 3 min time interval, resulting in an effective low dose rate of 0.067 Gy min
.
cell studies and
animal experiments demonstrated the therapeutic potential of PLDR treatments and provided useful preclinical data. Various treatment optimization strategies and delivery techniques have been developed for PLDR on existing linear accelerators. Preliminary results from early clinical studies have shown favorable outcomes for various treatment sites especially for recurrent cancers. This paper reviews the experimental findings of PLDR and dosimetric requirements for PLDR treatment planning and delivery, and summarizes major clinical studies on PLDR cancer treatments. |
| doi_str_mv | 10.1088/1361-6560/ac4c2f |
| format | Article |
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.
cell studies and
animal experiments demonstrated the therapeutic potential of PLDR treatments and provided useful preclinical data. Various treatment optimization strategies and delivery techniques have been developed for PLDR on existing linear accelerators. Preliminary results from early clinical studies have shown favorable outcomes for various treatment sites especially for recurrent cancers. This paper reviews the experimental findings of PLDR and dosimetric requirements for PLDR treatment planning and delivery, and summarizes major clinical studies on PLDR cancer treatments.</description><identifier>ISSN: 0031-9155</identifier><identifier>EISSN: 1361-6560</identifier><identifier>DOI: 10.1088/1361-6560/ac4c2f</identifier><identifier>PMID: 35038688</identifier><identifier>CODEN: PHMBA7</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>dose fractionation ; dose rate effect ; external beam radiotherapy (EBRT) ; Humans ; hyper-radiosensitivity ; Neoplasms - radiotherapy ; normal tissue toxicity ; Particle Accelerators ; pulsed low dose-rate radiotherapy (PLDR) ; Radiobiology ; Radiometry ; Radiotherapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; recurrent cancer</subject><ispartof>Physics in medicine & biology, 2022-01, Vol.67 (3), p.3</ispartof><rights>2022 Institute of Physics and Engineering in Medicine</rights><rights>2022 Institute of Physics and Engineering in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c298t-bba3ee9cd6ce57779e4c7cbeca0bbc2f91f5f3e233832163d002ebd90b4592d13</citedby><cites>FETCH-LOGICAL-c298t-bba3ee9cd6ce57779e4c7cbeca0bbc2f91f5f3e233832163d002ebd90b4592d13</cites><orcidid>0000-0002-5341-4827</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1361-6560/ac4c2f/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,776,780,27903,27904,53824,53871</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35038688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, C M Charlie</creatorcontrib><title>Pulsed low dose-rate radiotherapy: radiobiology and dosimetry</title><title>Physics in medicine & biology</title><addtitle>PMB</addtitle><addtitle>Phys. Med. Biol</addtitle><description>Pulsed low dose-rate radiotherapy (PLDR) relies on two radiobiological findings, the hyper-radiosensitivity of tumor cells at small doses and the reduced normal tissue toxicity at low dose rates. This is achieved by delivering the daily radiation dose of 2 Gy in 10 sub-fractions (pulses) with a 3 min time interval, resulting in an effective low dose rate of 0.067 Gy min
.
cell studies and
animal experiments demonstrated the therapeutic potential of PLDR treatments and provided useful preclinical data. Various treatment optimization strategies and delivery techniques have been developed for PLDR on existing linear accelerators. Preliminary results from early clinical studies have shown favorable outcomes for various treatment sites especially for recurrent cancers. This paper reviews the experimental findings of PLDR and dosimetric requirements for PLDR treatment planning and delivery, and summarizes major clinical studies on PLDR cancer treatments.</description><subject>dose fractionation</subject><subject>dose rate effect</subject><subject>external beam radiotherapy (EBRT)</subject><subject>Humans</subject><subject>hyper-radiosensitivity</subject><subject>Neoplasms - radiotherapy</subject><subject>normal tissue toxicity</subject><subject>Particle Accelerators</subject><subject>pulsed low dose-rate radiotherapy (PLDR)</subject><subject>Radiobiology</subject><subject>Radiometry</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>recurrent cancer</subject><issn>0031-9155</issn><issn>1361-6560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtLxDAURoMozji6dyWz04V1bpI-BRcy-IIBRcZ1yONWO7STmrRI_70t1VnpKtxwvu8mh5BTClcU0nRBeUyDOIphIXWoWb5HprurfTIF4DTIaBRNyJH3GwBKUxYekgmPgKdxmk7JzUtbejTz0n7NjfUYONng3ElT2OYDnay763FShS3tezeXWzOARYWN647JQS77_MnPOSNv93fr5WOwen54Wt6uAs2ytAmUkhwx0ybWGCVJkmGoE61QS1Cqf3ZG8yjnyDhPOaMxNwAMlclAhVHGDOUzcjH21s5-tugbURVeY1nKLdrWCxYzCozykPUojKh21nuHuahdUUnXCQpikCYGQ2IwJEZpfeTsp71VFZpd4NdSD5yPQGFrsbGt2_afFXWlRJwILoCvX4GK2gxVl3-Q_27-BkBBhAU</recordid><startdate>20220128</startdate><enddate>20220128</enddate><creator>Ma, C M Charlie</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5341-4827</orcidid></search><sort><creationdate>20220128</creationdate><title>Pulsed low dose-rate radiotherapy: radiobiology and dosimetry</title><author>Ma, C M Charlie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-bba3ee9cd6ce57779e4c7cbeca0bbc2f91f5f3e233832163d002ebd90b4592d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>dose fractionation</topic><topic>dose rate effect</topic><topic>external beam radiotherapy (EBRT)</topic><topic>Humans</topic><topic>hyper-radiosensitivity</topic><topic>Neoplasms - radiotherapy</topic><topic>normal tissue toxicity</topic><topic>Particle Accelerators</topic><topic>pulsed low dose-rate radiotherapy (PLDR)</topic><topic>Radiobiology</topic><topic>Radiometry</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>recurrent cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, C M Charlie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physics in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, C M Charlie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulsed low dose-rate radiotherapy: radiobiology and dosimetry</atitle><jtitle>Physics in medicine & biology</jtitle><stitle>PMB</stitle><addtitle>Phys. Med. Biol</addtitle><date>2022-01-28</date><risdate>2022</risdate><volume>67</volume><issue>3</issue><spage>3</spage><pages>3-</pages><issn>0031-9155</issn><eissn>1361-6560</eissn><coden>PHMBA7</coden><abstract>Pulsed low dose-rate radiotherapy (PLDR) relies on two radiobiological findings, the hyper-radiosensitivity of tumor cells at small doses and the reduced normal tissue toxicity at low dose rates. This is achieved by delivering the daily radiation dose of 2 Gy in 10 sub-fractions (pulses) with a 3 min time interval, resulting in an effective low dose rate of 0.067 Gy min
.
cell studies and
animal experiments demonstrated the therapeutic potential of PLDR treatments and provided useful preclinical data. Various treatment optimization strategies and delivery techniques have been developed for PLDR on existing linear accelerators. Preliminary results from early clinical studies have shown favorable outcomes for various treatment sites especially for recurrent cancers. This paper reviews the experimental findings of PLDR and dosimetric requirements for PLDR treatment planning and delivery, and summarizes major clinical studies on PLDR cancer treatments.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>35038688</pmid><doi>10.1088/1361-6560/ac4c2f</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-5341-4827</orcidid></addata></record> |
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| ispartof | Physics in medicine & biology, 2022-01, Vol.67 (3), p.3 |
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| source | MEDLINE; IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | dose fractionation dose rate effect external beam radiotherapy (EBRT) Humans hyper-radiosensitivity Neoplasms - radiotherapy normal tissue toxicity Particle Accelerators pulsed low dose-rate radiotherapy (PLDR) Radiobiology Radiometry Radiotherapy Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods recurrent cancer |
| title | Pulsed low dose-rate radiotherapy: radiobiology and dosimetry |
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