Unsupervised domain adaptation model for lesion detection in retinal OCT images

Optical coherence tomography (OCT) is one of the most used retinal imaging modalities in the clinic as it can provide high-resolution anatomical images. The huge number of OCT images has significantly advanced the development of deep learning methods for automatic lesion detection to ease the doctor's workload. However, it has been frequently revealed that the deep neural network model has difficulty handling the domain discrepancies, which widely exist in medical images captured from different devices. Many works have been proposed to solve the domain shift issue in deep learning tasks such as disease classification and lesion segmentation, but few works focused on lesion detection, especially for OCT images. In this work, we proposed a faster-RCNN based, unsupervised domain adaptation model to address the lesion detection task in cross-device retinal OCT images. The domain shift is minimized by reducing the image-level shift and instance-level shift at the same time. We combined a domain classifier with a Wasserstein distance critic to align the shifts at each level. The model was tested on two sets of OCT image data captured from different devices, obtained an average accuracy improvement of more than 8% over the method without domain adaptation, and outperformed other comparable domain adaptation methods. The results demonstrate the proposed model is more effective in reducing the domain shift than advanced methods.