Targeted polyethylenimine/(p53 plasmid) nanocomplexes for potential antitumor applications

Targeted polyethylenimine/(p53 plasmid) nanocomplexes for potential antitumor applications

The development of the tumor-targeting ability of nanocarriers is of paramount importance for gene delivery into tumor lesions as well as to avoid biotoxicity. Here we report the synthesis of the polyethyleneimine-fluorescein isothiocyanate-folic acid (PEI-FITC-FA) polymer, which could condense the...

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Veröffentlicht in:Nanotechnology 2019-04, Vol.30 (14), p.145601
Hauptverfasser: Zhong, Yuan, Wang, Yi, Luo, Li, Nurhidayah, Deti, Maruf, Ali, Gregersen, Hans, Wu, Wei, Wang, Gui-Xue
Format: Artikel
Sprache:eng
Schlagworte:
antitumor
fluorescence
gene therapy
nano-complex
targeted delivery
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Zusammenfassung:The development of the tumor-targeting ability of nanocarriers is of paramount importance for gene delivery into tumor lesions as well as to avoid biotoxicity. Here we report the synthesis of the polyethyleneimine-fluorescein isothiocyanate-folic acid (PEI-FITC-FA) polymer, which could condense the tumor suppressor pp53 to form nanocomplexes. These targeted nanocomplexes exhibited favorable physical properties including a small size of
ISSN:0957-4484
1361-6528
DOI:10.1088/1361-6528/aaf41a