Multicomponent design of chromeno[2,3-b]pyridine systems

The review summarizes and systematizes data on the methods for the preparation of chromeno[2,3-b]pyridines. Both multicomponent and pseudo-multicomponent synthetic approaches and one-pot transformations based on the reactions of carbonyl compounds, malononitrile or its derivatives, and CH-acids are considered. Examples of the use of various catalysts, microwave and ultrasonic radiation, as well as electric current for the implementation of multicomponent transformations of this type are given. Characteristic features of the course and mechanisms of reactions are discussed. Data on the biological activity of the obtained compounds and on other fields of application of such heterocyclic systems are presented. The bibliography includes 109 references.