Involvement of dopamine D1 receptors of the hippocampal dentate gyrus in spatial learning and memory deficits in a rat model of vascular dementia

We investigated the involvement of dopamine (DA) and its D1 receptors of the hippocampal dentate gyrus (DG) in spatial learning and memory deficits in a rat model of vascular dementia (VD) established by permanent bilateral carotid occlusion. Spatial learning and memory abilities of rats were measur...

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Veröffentlicht in:	Pharmazie 2014-09, Vol.69 (9), p.709-710
Hauptverfasser:	Wan, P, Wang, S, Zhang, Y, Lv, J, Jin, Q H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carotid Stenosis - physiopathology Carotid Stenosis - psychology Dementia, Vascular - psychology Dentate Gyrus - physiopathology Dopamine - metabolism Male Maze Learning - drug effects Memory Disorders - psychology Microdialysis Microinjections Rats Rats, Sprague-Dawley Receptors, Dopamine D1 - drug effects Space Perception - drug effects
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Zusammenfassung:	We investigated the involvement of dopamine (DA) and its D1 receptors of the hippocampal dentate gyrus (DG) in spatial learning and memory deficits in a rat model of vascular dementia (VD) established by permanent bilateral carotid occlusion. Spatial learning and memory abilities of rats were measured by Morris water maze, and extracellular concentrations of DA in the DG were determined by in vivo microdialysis. The DA concentrations in the DG decreased in the VD rats compared with sham-operated group. Microinjection of SFK38393 (D1 receptor agonist) into the DG attenuates spatial learning and memory deficits in the VD rats.
ISSN:	0031-7144
DOI:	10.1691/ph.2014.4602