Anti-diabetic effect of Murraya koenigii leaves on streptozotocin induced diabetic rats

The present study was aimed to evaluate the anti-hyperglycemic efficacy of Murraya koenigii in STZ-induced diabetic rats. Oral administration of ethanolic extract of M. koenigii at a dose of 200 mg/kg/b.w./day for a period of 30 days significantly decreased the levels of blood glucose, glycosylated...

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Veröffentlicht in:	Pharmazie 2006-10, Vol.61 (10), p.874-877
Hauptverfasser:	Arulselvan, P., Senthilkumar, G. P., Sathish Kumar, D., Subramanian, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Blood Proteins - metabolism Blood Urea Nitrogen Body Weight - drug effects Creatinine - blood Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Glucose Tolerance Test Glyburide - pharmacology Glycated Hemoglobin A - metabolism Hemoglobins - metabolism Hypoglycemic Agents - therapeutic use Male Murraya - chemistry Plant Leaves - chemistry Rats Rats, Wistar Uric Acid - urine
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Zusammenfassung:	The present study was aimed to evaluate the anti-hyperglycemic efficacy of Murraya koenigii in STZ-induced diabetic rats. Oral administration of ethanolic extract of M. koenigii at a dose of 200 mg/kg/b.w./day for a period of 30 days significantly decreased the levels of blood glucose, glycosylated hemoglobin, urea, uric acid and creatinine in diabetic treated group of animals. Determination of plasma insulin level revealed the insulin stimulatory effect of the extract. The results suggest that M. koenigii possesses statistically significant hypoglycemic potential in STZ-induced diabetic rats. The M. koenigii extract appeared to be more effective than glibenclamide, a known antidiabetic drug.
ISSN:	0031-7144