Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats

This study examined the effects of simvastatin (10 mg/kg) and VULM 1457 (50 mg/kg), an ACAT inhibitor, in the heart model of 6 min ischemia followed by 10 min reperfusion injury in the diabetic-hypercholesterolaemic (DM-HCH) rats. In the DM-HCH rats, the incidence of ventricular tachycardia (VT) had...

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Veröffentlicht in:	Pharmazie 2006-09, Vol.61 (9), p.807-808
Hauptverfasser:	Adameová, A., Kuželová, M., Faberová, V., Švec, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - prevention & control Blood Glucose - metabolism Cholesterol - blood Cholesterol - metabolism Cholesterol, Dietary Clofibrate - analogs & derivatives Clofibrate - therapeutic use Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - physiopathology Enzyme Inhibitors - therapeutic use Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypercholesterolemia - chemically induced Hypercholesterolemia - complications Hypercholesterolemia - physiopathology Male Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Rats Rats, Wistar Reperfusion Injury - pathology Reperfusion Injury - prevention & control Simvastatin - therapeutic use Sterol O-Acyltransferase - antagonists & inhibitors
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Zusammenfassung:	This study examined the effects of simvastatin (10 mg/kg) and VULM 1457 (50 mg/kg), an ACAT inhibitor, in the heart model of 6 min ischemia followed by 10 min reperfusion injury in the diabetic-hypercholesterolaemic (DM-HCH) rats. In the DM-HCH rats, the incidence of ventricular tachycardia (VT) had a tendency to be increased, while ventricular fibrillation (VF) occurred in all diseased rats (p < 0.01). Simvastatin and VULM 1457 with the shown hypolipidemic effect, significantly (p < 0.01) suppressed a formation of VF (38% and 29%; respectively).
ISSN:	0031-7144