Mhc Gene Products and Anticardiolipin Antibodies in Systemic Lupus Erythematosus Results of a Multicenter Study

Mhc Gene Products and Anticardiolipin Antibodies in Systemic Lupus Erythematosus Results of a Multicenter Study

Anticardiolipin antibodies (aCL) and HLA-DR antigens were determined in 314 central European patients with systemic lupus erythematosus (SLE). Both HLA-DR4 and DR7 were increased in aCL-positive patients, and aCL were significantly associated with DRw53. The association between DRw53 and aCL was als...

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Veröffentlicht in:Autoimmunity (Chur, Switzerland) Switzerland), 1992, Vol.13 (2), p.95-99
Hauptverfasser: Hartung, K., Coldewey, R., Corvetta, A., Deicher, H., Kalden, J. R., Krapf, F., Lang, B., Lakomek, H. J., Liedvogel, B., Peter, H. H., Schendel, D., Specker, Ch, Stangel, W.
Format: Artikel
Sprache:eng
Schlagworte:
antiphospholipid antibody
Biological and medical sciences
cardiolipin
complement
genetics
major histocompatibility complex
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Systemic lupus erythematosus
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Zusammenfassung:Anticardiolipin antibodies (aCL) and HLA-DR antigens were determined in 314 central European patients with systemic lupus erythematosus (SLE). Both HLA-DR4 and DR7 were increased in aCL-positive patients, and aCL were significantly associated with DRw53. The association between DRw53 and aCL was also apparent in those 17 patients with SLE and the anticardiolipin syndrome. There was no association between aCL and HLA-DQ or C4 alleles in SLE.
ISSN:0891-6934
1607-842X
DOI:10.3109/08916939209001909