Recurrent Acute Renal Failure with Interstitial Nephritis Due to D-Penicillamine

A 60-year-old man with rheumatiod arthritis, who developed acute reversible renal failure with nephrotic syndrome and tubulointerstitial nephritis in association with multiple-drug therapy, is described. The episode was ascribed to the nonsteroidal anti-inflammatory agent fenbufen, and the patient w...

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Veröffentlicht in:Renal failure 1987, Vol.10 (1), p.55-57
Hauptverfasser: Feehally, J., Wheeler, D. C., Mackay, E. H., Oldham, R., Walls, J.
Format: Artikel
Sprache:eng
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Zusammenfassung:A 60-year-old man with rheumatiod arthritis, who developed acute reversible renal failure with nephrotic syndrome and tubulointerstitial nephritis in association with multiple-drug therapy, is described. The episode was ascribed to the nonsteroidal anti-inflammatory agent fenbufen, and the patient was reexposed to D-penicillamine within 6 months, reproducing the same renal lesion. There was no evidence of the glomerular lesions characteristically associated with D-penicillamine nephrotoxicity. D-penicillamine was the only drug therapy common to both episodes and it is concluded that it may cause tubulointerstitial nephritis with nephrotic syndrome.
ISSN:0886-022X
1525-6049
DOI:10.3109/08860228709047645