Radioiron Utilization and Gossypol Acetic Acid in Male Rats

ABSTRACT The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant...

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Veröffentlicht in:	Drug Chem. Toxicol.; (United States) 1985, Vol.8 (1-2), p.69-82
Hauptverfasser:	Tone, J. N., Jensen, D. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics ANIMAL TISSUES ANIMALS BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOLOGICAL MATERIALS BIOLOGICAL WASTES BLOOD BLOOD CELLS BLOOD FORMATION BODY BODY FLUIDS Body Weight - drug effects BONE MARROW CELL KILLING DAYS LIVING RADIOISOTOPES DIGESTIVE SYSTEM DRUGS ERYTHROCYTES Erythrocytes - metabolism ERYTHROPOIESIS Erythropoiesis - drug effects EVEN-ODD NUCLEI GAMETES GERM CELLS GLANDS Gossypol - analogs & derivatives Gossypol - toxicity HEMATOPOIETIC SYSTEM INTERMEDIATE MASS NUCLEI Iron - metabolism IRON 59 IRON COMPOUNDS IRON ISOTOPES Iron Radioisotopes ISOTOPES LIVER Male MAMMALS MATERIALS MEDICINE METABOLISM MUSCLES NUCLEI ORGANS RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE RATS RODENTS Spermatocidal Agents - toxicity SPERMATOZOA SPLEEN SPLENECTOMY SURGERY TISSUES TRANSITION ELEMENT COMPOUNDS URINE VERTEBRATES WASTES WEIGHT
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Zusammenfassung:	ABSTRACT The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weight gain was observed in all GAA treated animals. Splenectomized rats dosed with GAA exhibited a significant decrease in hemoglobin concentration, hematocrit and erythrocyte count. A significant increase in 59Fe incorporation by red blood cells and a decrease in hepatic incorporation of 59Fe indicate a preferential utilization of iron in erythropoiesis among GAA treated animals.
ISSN:	0148-0545 1525-6014
DOI:	10.3109/01480548509011635