Trend towards Decreased Survival in Patients Infected with HIV Resistant to Zidovudine

The survival of 35 patients with AIDS or advanced HIV infection on treatment with zidovu-dine was related to the viral sensitivity to the drug and to the CD4+ cell count. 14 patients died, the survivors were followed up for an average of 804 days. In a univariate Cox model, survival was strongly rel...

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Veröffentlicht in:	Scandinavian journal of infectious diseases 1992, Vol.24 (5), p.563-565
Hauptverfasser:	Gøtzsche, Peter C., Nielsen, Claus, Gerstoft, Jan, Nielsen, Carsten M., Vestergaard, Bent F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - mortality Adult AIDS/HIV CD4-Positive T-Lymphocytes Double-Blind Method Drug Resistance, Microbial Female HIV Infections - blood HIV Infections - drug therapy HIV Infections - mortality Humans Leukocyte Count Male Survival Rate - trends Zidovudine - therapeutic use
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Zusammenfassung:	The survival of 35 patients with AIDS or advanced HIV infection on treatment with zidovu-dine was related to the viral sensitivity to the drug and to the CD4+ cell count. 14 patients died, the survivors were followed up for an average of 804 days. In a univariate Cox model, survival was strongly related to Iog IC90 (p = 0.0003) and to the CD4+ count (p = 0.0002). In a bivariate model, Iog IC90 and the CD4+ count contributed to the prediction of survival (p = 0.12 and 0.06, respectively). Large studies of combination or alternation therapy with several anti-HIV drugs should be given high priority.
ISSN:	0036-5548 1651-1980
DOI:	10.3109/00365549209054641