Changes in Levels of Mucosal Glycoprotein on Cysteamine-Induced Duodenal Ulcers in Rats

Duodenal ulcers were induced in rats by cysteamine administration. Time-course changes in duodenal hexo-samine, blood flow and intragastric pH were measured, as well as changes in the susceptibility of Brunner's glands to concanavalin A (Con A) staining. Hexosamine contents in the duodenum decreased significantly at 5 and 24 h. In the control group, Brunner's glands were stained brown using Con A staining. One day after cysteamine administration, the extent of Con A staining markedly decreased. At 3 and 7 days, gland susceptibility to staining was essentially the same as that of the control group.