The mechanism of action of Bay g 2821: a new diuretic

Summary Acute water diuresis and hydropenic studies were carried out in 7 healthy volunteers to investigate the site of action of a new non-sulphonamide diuretic, Bay g 2821. The effects of the drug on the concentrating and diluting mechanism, and on the renal handling of sodium, potassium, calcium,...

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Veröffentlicht in:	Current medical research and opinion 1977, Vol.4 (7), p.462-468
Hauptverfasser:	Mussche, M., Lameire, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bay g 2821 Calcium - metabolism Diuresis - drug effects Diuretics Diuretics - pharmacology Female Humans Kidney Tubules - drug effects Male pharmacology Pyrazoles - pharmacology Sodium - metabolism Time Factors Water Deprivation
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Zusammenfassung:	Summary Acute water diuresis and hydropenic studies were carried out in 7 healthy volunteers to investigate the site of action of a new non-sulphonamide diuretic, Bay g 2821. The effects of the drug on the concentrating and diluting mechanism, and on the renal handling of sodium, potassium, calcium, phosphorus and uric acid were studied. The results suggest sites of actions of Bay g 2821 at the proximal tubule and the medullary portion of the ascending limb of the loop ofHenle.
ISSN:	0300-7995 1473-4877
DOI:	10.1185/03007997709109334