Morning pseudoneutropenia during clozapine treatment

Morning pseudoneutropenia during clozapine treatment

Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The World Journal of Biological Psychiatry 2003, Vol.4 (4), p.192-194
Hauptverfasser: Esposito, David, Aouillé, Jérémie, Rouillon, Frédéric, Limosin, Frédéric
Format: Report
Sprache:eng
Schlagworte:
clozapine
diurnal variation
schizophrenia
transient neutropenia
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900/mm 3 in the morning and 2200- 2700/mm 3 in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment.
ISSN:1562-2975
1814-1412
DOI:10.1080/15622970310029918