8-Substituted Adenine β-D-Xylofuranosides and α-L-Arabinofuranosides

8-Substituted Adenine β-D-Xylofuranosides and α-L-Arabinofuranosides

9-(β-D-Xylofuranosyl) adenine and 9-(α-L-arabinofuranosyl)-adenine have been modified to give a series of 8-amino-substituted nucleosides. Convenient methods of halogenation of these nucleosides and reactions of 8-halogenated nucleosides with various amines are described. No significant cytotoxic or...

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Veröffentlicht in:Nucleosides & nucleotides 1995-10, Vol.14 (8), p.1709-1724
Hauptverfasser: Jansons, Janis, Maurinsh, Yuris, Lidaks, Margeris
Format: Artikel
Sprache:eng
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Zusammenfassung:9-(β-D-Xylofuranosyl) adenine and 9-(α-L-arabinofuranosyl)-adenine have been modified to give a series of 8-amino-substituted nucleosides. Convenient methods of halogenation of these nucleosides and reactions of 8-halogenated nucleosides with various amines are described. No significant cytotoxic or antiviral activity was found.
ISSN:0732-8311
DOI:10.1080/15257779508009752